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Authors: Ramis R. Gizzatullin, candidate of veterinary sciences, gizzatullin.1987@bk.ru Minsagit K. Lutfullin, doctor of veterinary sciences, parasitology-kazan@mail.ru Danil N. Mingaleev, doctor of veterinary sciences, damin80@mail.ru Ramia R. Gizzatullina, candidate of veterinary sciences, gizzatullina.miya@bk.ru Rosalia R. Timerbayeva, candidate of veterinary sciences, 89033401420@mail.ru
Address: Kazan State Academy of Veterinary Medicine named after N.E. Bauman, Kazan, Russia
Abstract. Aimeriosis is one of the most common diseases of birds caused by protozoa, which leads to a decrease in productivity and economic losses in poultry farming. In this study, the anti-eimeriosis efficacy of the new pharmacological substance "K-55" was studied in the treatment of chickens infected with eimeriosis. Under the guidance of teachers of the Department of Epizootology and Parasitology, an experiment was carried out on 30 chickens of twenty-day age who were infected with a titrated dose of sporulated cocystameria at a dose of 2000 cells per 1 kg of weight. The results of the studies showed that subacute and desquamative catarrhal inflammation was observed in the control groups in the small intestine of chickens experimentally infected with eimeriosis. In some areas of the intestinal wall, the destruction of not only the villi, but also the entire epithelial monolayer of the crypt is noticeable. The hydrographic structure of the small intestine was preserved on the 7th and 14th days after 69
treatment with the pharmacological substance "K-55". In the intestine there were villi with a flattened and wide base. The prisms in the villi were represented by a multitude of goblet-shaped exocrinoids, with signs of increased secretion. No hypersecretion was detected in the apical zone. The dense base of the villi is characterized by hyper- plasia of reticulocytes, fibroblasts and endothelial cells of blood vessels. Apparently, the muscle layer consisted of a continuous and uneven layer. The study showed that the new pharmacological substance "K-55" is effective in the treatment of avian eimeriosis.
Keywords: Keywords: eimeriosis, extens and intensities, chickens, pathomorphological and histochemical changes
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3. 3.Gizzatullin, R.R. Comparative pathomorphological assessment of the effect of the compound "Degelm-14" and the drug amprolium on the liver and small intestine of chickens with eimeriosis / R.R. Gizzatullin, I.N. Zalyalov, M.H. Lutfullin // Scientific notes of the Kazan State Academy of Veterinary Medicine named after 72
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5. 6.Zalyalov, I.N. Pathomorphological evaluation of the effectiveness of the compound "Degelm 14 at eimeriosis of chickens / I.N. Zalyalov, R.R. Gizzatullin, and M. Idrisov // Scientific notes of the Kazan State Academy of Veterinary Medicine named after N.E. Bauman, Vol 227. – 2010. - ¹1. – Pp.42-47.
6.   7.Lutfullin, M.H. Eimeriosis of chickens / M.H. Lutfullin, N.A. Lutfullina, I.N. Zalyalov, R.R. Gizzatullin, I.V. Galkina // Kazan State Academy of Veterinary Medicine, – Kazan, 2015.-101c.
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Authors: Arkif R. Mustafayev , candidate of veterinary sciences, mustafaev_arkif@mail.ru Enver A. Ivashov , Ivashev47@mail.ru Magomed O. Baratov , doctor of veterinary sciences, alama500@rambler.ru
1, 3 The Caspian Zonal Veterinary Research Institute is a branch of the Federal State Budgetary Scientific In- stitution "Federal Agrarian Scientific Center of the Republic of Dagestan", Makhachkala, Russia
2 Republican Veterinary Laboratory of the Republic of Dagestan, Makhachkala, Russia
Abstract. The article provides retrospective data on the radiation background. Epizootic analysis of bovine leukemia in the Republic of Dagestan was carried out. In different periods the level of background radiation in the republic changed in different ways. So, in 1986, after the Chernobyl accident, we recorded excess of the permissible content of radioactive isotopes in samples ( Sr in seeded hay (586.7±70 pCi/kg 10-
12); 137Cs in natural hay (8801±6000 pCi/kg 10-12); 210Pb in meat (cattle) (6,9± 1,3 pCi/kg 10-12). In 1987 the 52
content of radioactive substances in samples in the republic was also at a high level. The indicators for the total beta activity of radionuclides in the samples (in straw - 18.8±2.6 nCi/kg 10-9, etc.) increased several times, and the gamma radiation emitted by radionuclides exceeded the maximum permissible norms until 1990. In 2011-2012, we also recorded a slight excess of radioactive substances in the studied samples ( Sr in meat 
(30.3±14.3 pCi/kg 10-12 (2011), 33.7±12.1 pCi/kg 10-12 (2012)); 137Cs in seeded hay (295.7±98.4 pCi/kg 10- 12 (2011), 210.7±52.3 pCi/kg 10-12(2012)), etc. The article presents data on the spread of BLV in the republic among animals in different periods of time. In the period after the Chernobyl accident (1988-1991), the inci- dence of bovine leukemia ranged from 3.4% (1992) to 13.2% (1991), and the percentage of infection with BLV reached from 13.2% (1992) to 32.2% (1988). From 2010 to 2014 the infection rate of BLV ranged from 2.9% (2012) to 23% (2010), and the incidence of bovine leukemia during this period did not fall below 16.7%. Thus, the excess of the content of radioactive isotopes in the samples was noted in different periods of time. During the studied period high level of bovine leukemia was observed in parallel.
Keywords: Keywords: leukemia of cattle, seropositivity, radiation background, radioactive isotopes ( Sr, 210 Pb), total β-activity, γ-radiation, Republic of Dagestan. 90 137Cs,
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Authors: Alexey V. Frolov , doctor of biological sciences, frolov012@list.ru Nikolay M. Vasilevsky , doctor of veterinary sciences, vnickm@list.ru Ekaterina N. Maiorova , candidate of biological sciences, majorovaen83@list.ru Rustam N. Nizamov , candidate of veterinary sciences, rstm1@ya.ru Mikhail I. Medvedev , mr.mixail777@mail.ru
Address: 1, 2, 3, 4, 5 Federal Center for Toxicological, Radiation, and Biological Security, Kazan, Russia
Abstract. In the course of the research, the purpose of which was to develop a feed additive capable of reducing the sensitivity of the animal body to the action of ionizing radiation, the radioprotective effective- ness of experimental variants of feed additives – compositions was evaluated ¹ 2, ¹ 3, ¹ 4, ¹ 5 and No. 7, who showed the most pronounced stimulating effect in the course of previous studies. Experiments were con- ducted on white mice with a live weight of 18-20 g, from which groups of 12 heads were formed. The compo- sitions were given in a mixture with feed in the amount of 2 and 5% of the feed weight. The therapeutic, prophylactic and therapeutic-prophylactic effect of the studied compositions in acute radiation sickness was evaluated, for which the survival rate of animals on 3, 6, 10, 14, 21, 30 a day after irradiation, the average life 
expectancy of the victims was calculated. The irradiation was carried out on a gamma-ray installation "PUMA" with a source of ionizing radiation 137Cs. In the first experiment, the radiation dose was 7.7 Gy (LD100/30), in the second – 6.6 Gy (LD50/30). The results of the studies have shown that compositions No. 5 and No. 7 increase the average life expectancy of white mice exposed to gamma radiation at a dose of 7.7 Gy, they are most effective for preventive and therapeutic use in an amount of 5% of the feed weight; of the tested prepa- rations, the maximum radioprotective effect on white mice exposed to gamma radiation at a dose of 6.6 G, compositions No. 2, No. 3, No. 5 are shown in an amount of 5% of the feed weight.
Keywords: Keywords: radiation sickness, radioprotective composition, prophylactic effect, therapeutic effect, therapeutic and prophylactic effect
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Authors: Andrey Vitalievich Makarov 1, doctor of biological sciences, Associate Professor, andmak83@yandex.ru Radosvet Dmitrievich Zemlyansky 2, Master, radosvet2001@gmail.com
1 Krasnoyarsk State Agrarian University, Krasnoyarsk, Russia
2 Omsk State Agrarian University named after P.A. Stolypin, Omsk, Russia
Abstract: One of the most dangerous diseases for humans and animals, with a high chance of death, is anthrax. The causative agent of anthrax spreads alimentally, contact, when it enters wounds, and there is also the possibility of transmissible transmission of the pathogen. However, all transmission factors are possi- ble only due to the presence of anthrax bacilli spores, as a result of which this microorganism can be in the soil for centuries. One of the main sources of the causative agent of anthrax infection are burials and animal burial grounds, the destruction of which is a difficult task. During the disposal of burials, the absolute decontamina- tion of microbial spores up to 100% is an almost unattainable goal. Gamma radiation is a type of electromag-44
netic radiation, which is a stream of gamma quanta, depending on the energy and isotope, it has a high pene- trating effect, while having the property of disinfecting microorganisms. Gamma radiation is used for disin- fection of wastewater, as well as disinfection of agricultural products.
This article analyzes the theoretical aspects of the use of gamma radiation for disinfection of anthrax burials. The use of gamma radiation for disinfection of vegetative and spore cells of the bacterium Bacillus anthracis – anthrax bacillus is considered. Radioactive isotopes are characterized, the possibility of using which is most appropriate for use for the purpose of neutralization of burials and animal burial grounds. The concept of the possibility of using radioactive isotopes for disinfection of microorganisms is formulated. Some physical characteristics of gamma radiation and properties of some radioactive isotopes are calculated for theoretical justification, possible use of the proposed method of disinfection of burials and animal burial grounds. The constructed model of decontamination of animal burial grounds and anthrax burials.
Keywords: Keywords: anthrax, spores, bacteria, animal burial grounds, burials, gamma radiation, radioactive iso- topes, disinfection
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Authors: Egor Andreevich Glazunov , candidate of biological sciences, glazunov@micromir.bio Egor Anatolyevich Pustovit , postgraduate student of the Department of Immunology and Biotechnology, egor_pustovit@mail.ru Nikolay Vasilyevich Pimenov , doctor of biological sciences, pimenov-nikolai@yandex.ru Yana Andreevna Yuskevich , researcher
Egor Andreevich Glazunov , candidate of biological sciences, glazunov@micromir.bio
Egor Anatolyevich Pustovit , postgraduate student of the Department of Immunology and Biotechnology, egor_pustovit@mail.ru
Nikolay Vasilyevich Pimenov , doctor of biological sciences, pimenov-nikolai@yandex.ru Yana Andreevna Yuskevich , researcher
Abstract: Abstract. Otitis externa is a common pathological condition in dogs and cats that requires antimicrobial therapy. The ubiquitous increasing number of bacteria resistant to antibiotics confirms the need to use alternative antibacterial agents. The search and improvement of technological methods for the isolation of bacteriophages will increase the effectiveness of existing products, expand the possibilities of creating new cosmetic and medicinal products, create a springboard for individual therapy. These studies are devoted to the study of the possibility of using ultrafiltration methods for the search and concentration of viruses in order to improve the process of pharma- ceutical development of drugs based on bacteriophages for the treatment of external otitis in dogs and cats. The effectiveness of ultrafiltration of bacteriophage suspensions to Escherichia coli, Klebsiella pneumoniae, Pseudo- monas aeruginosa, Streptococcus agalactiae, Staphylococcus aureus was determined in order to concentrate them using ultrafiltration cells with a volume of 400 ml and ultrafiltration discs with a pore diameter of 500, 300 and 100 kDa. At an operating pressure of 3 to 4 bar, viruses pass through filtration membranes with a pore diameter of 500 and 300 kDa, but are delayed at 100 kDa. The research results demonstrate the possibility of using ultrafiltration methods to increase the chance of detecting the bacteriophages in the primary material. According to the results of the research, it was found that the ultrafiltration technique is suitable for searching and concentrating bacteriophages to pathogenic and facultative pathogenic bacterial species of dogs and cats, while the loss of bacteriophages using 
Keywords: Keywords: Bacteriophages, ultrafiltration, virus concentration, otitis externa, dogs, cats, veterinary bio- technology.
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Authors: Melikova Yulia Nikolaevna, candidate of veterinary sciences, melikovayn@mgupp.ru
Address: Federal State Budgetary Educational Institution of Higher Education "Russian Biotechnological University", Moscow, Russia
Abstract. The article presents a scientifically based approach to the diagnosis and prognostic analysis of immunohistochemical studies of spontaneous dermal mastocytomas in dogs. The work uses a comprehensive meth- odological approach, including methods of clinical, pathomorphological, instrumental research. The research in- volved 198 dogs with various malignant neoplasms of the skin, of which 64 were mastocytomas, including 42 cases in the area of the facial part of the skull.
It was determined that in dogs mastocytomas in the area of the facial part of the skull, compared with other localizations, have a more unfavorable prognosis in treatment due to difficulties in complying with the rules of surgical intervention. Most often, mastocytomas of the facial part of the skull are localized on the ribs and in the chin area, less often in the eyelid area, on the oral mucosa. When using two immunohistochemical markers CD117 (KIT) and ki-67, a prognostically important relationship was revealed with the degree of malignancy, complexity of treatment and progression of mastocytomas during treatment. It is shown that the interpretation of these markers was reliable in all cases of observation of sick animals. Data analysis revealed a correlation between increased ki- 67 expression, as well as aberrant CD117 immunoexpression (KIT) and morphological malignancy, which is an 11
unfavorable prognostic factor (median survival is decreasing) in dogs with spontaneous dermal mastocytomas. Thus, immunohistochemical studies using CD117 (KIT) and ki67 markers may have prognostic significance and value in addition to other special studies of spontaneous dermal mastocytomas in dogs.
Keywords: Keywords: Dog, neoplasm, mastocytoma, morphological studies, immunohistochemical studies, CD117 (KIT), ki-67, prognosis.
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Authors: Taras V. Gerunov , doctor of biological sciences, associate professor, tv.gerunov@omgau.org Vladimir I. Gerunov , doctor of veterinary sciences, professor, vi.gerunov@omgau.org Yury N. Fedorov , doctor of biological sciences, Corresponding Member of the Russian Academy of Sciences, Professor, fun181@mail.ru Marina N. Gonokhova , candidate of veterinary sciences, associate professor, gonochova@mail.ru Yana O. Kryuchek graduate student, yao.kryuchek36.06.01@omgau.org
1,2,5 Omsk State Agrarian University named after P.A. Stolypin, Omsk, Russia
3 All-Russian Research and Technological Institute of Biological Industry, Biokombinat settlement, Shchelkov- skii District, Moscow Region, Russia
4 Omsk State Medical University, Omsk, Russia
Abstract. Industrial livestock production causes numerous stress factors that animals face. The combined effect of these stressors is ecpecially dangerous for them. This study was aimed at assessing the risks of immuno- suppression in pigs that were treated with eprinomectin against parasites and received feed contaminated with my- cotoxins. Two groups of pigs aged 100-110 days (n=10) were used in the experiment. The first group was control, and its animals were given good food without mycotoxins. Pigs from the second group received food containing deoxynivalenol (0.93 mg/kg), T-2 toxin (0.025 mg/kg), and zearalenone (less than 0.02 mg/kg) for 45 days. Also, on the 38th day of the experiment, the experimental group underwent a single antiparasitory treatment with the medical drug Veteprin (the active substance – eprinomectin). The dose was 300 mcg/kg. Seven days after injection of the drug, blood tests were taken to determine the immunological indicators. It was found that the combined effect of mycotoxins and eprinomectin did not affect the leucocytes content, but the proportion of lymphocytes increased by 9.8%, mainly due to an increase in absolute and percentage number of B-lymphocytes. The T-lymphocytes level decreased to 1.0×10 /liter, while its level in animals of the control group was 1.3×10 /liter. The animals in the 
experimental group also had a lower indicator of the stimulated NBT test, and the calculated coefficient of granu- locyte stimulation fell by 6.8%. Histological examination of the thymus of these animals revealed narrowing of the cortical substance and the appearance of pronounced Hassall’s corpuscles. In the white pulp of the spleen and mes- enteric lymph nodes, a decrease in the density of lymphocytes, blood filling of blood vessels, swelling and thicken- ing of blood vessel walls, and fragmentary loosening of connective tissue were revealed. The results of the study indicate that animals that face the combined effects of toxicants have a high risk of immunosuppression, which increases the likelihood of infectious diseases.
Keywords: Keywords: mycotoxins, deoxynivalenol, T-2 toxin, zearalenone, antiparasitic agents, eprinomectin, thy- mus, spleen, lymph node, immunosuppression.
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Authors: Roman N. Melnik , candidate of biological sciences, mromanos@mail.ru Oleg A. Revvo , revvo_oavet@mail.ru Nikolay V. Melnik , doctor of veterinary sciences, melniknv@biocombinat.ru Viktor Yu. Petrov , c666ea@mail.ru Natalia V. Haustova , khaustovanv@biocombinat.ru Vyacheslav A. Starikov , candidate of veterinary sciences, starikovva@biocombinat.ru Vladimir N. Borovoy , candidate of veterinary sciences, borovoi_vn@mail.ru Ekaterina V. Pankova , candidate of biological sciences, katerinka_ja@bk.ru
 All-Russian Scientific Research and Technological Institute of the Biological Industry, Losino-Petrovsky, Moscow Region, Russia
2 All-Russian State Research Institute of Control, Standardization, and Certification of Veterinary Preparations, Moscow, Russia
3 Federal State Budgetary Scientific Institution «Federal Center for Toxicological, Radiation and Biological safety», Kazan, Russia 
Abstract: Abstract. The article presents scientific research on the development and design of formulations of univer- sal baits for self-vaccination of wild boars against African swine fever and other infectious diseases (methods of vaccine delivery to wild target animals). The ways of the spread of African swine fever and other infections, methods and ways to reduce the risk of introducing the pathogen, the main goals of preventive vaccination, its tasks are shown. The characteristics and composition of the briquette-baits and the requirements for their design are shown. The photo shows some samples of universal baits for delivering any vaccine to target animals for self-vaccination. Based on the foregoing, one of the tasks in addition to creating an ASF vaccine is to create baits for wild boar, which can not be parenterally immunized. For oral vaccination against African swine fever approaches to be successful, it is necessary to develop baits that meet a number of requirements: be attractive to the target animal species; ensure that an effective dose of the vaccine enters the animal; ensure the safety of the vaccine without compromising its effectiveness; be free from outside agents; not attract non-target species, including humans; be safe for target and non-target species; enable industrial production. One of the decisive factors in ensuring oral vaccination coverage is the palatability of the bait. The following factors influence the palatability of the bait: smell. taste, texture, shape and size of the bait. Based on the results of the analysis of scientific data. We concluded that in an endemic situation, where control measures (killing, zoning with restrictive measures) are insufficient, systematic vaccination based on the use of an oral vaccine may be an appropriate tool to control ASF in the wild boar population.
Keywords: Keywords: baits, classical swine fever, african swine fever, wild boar, oral vaccination
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Authors: Gennady N. Spiridonov, doctor of biological sciences, spiridonovkzn57@gmail.com Danil N. Mingaleev, doctor of veterinary sciences, damin80@mail.ru Milyausha T. Khuramshina, Khuramshina@mail.ru Aidar F. Makhmutov, candidate of biological sciences, Makhmutov.aidar@bk.ru Anton G. Spiridonov, candidate of biological sciences, mrtkzn@gmail.com Svetlana V. Ivanova, candidate of biological sciences, 9274281396@mail.ru Maksim A. Kosarev, candidate of biological sciences, kosarev@vnivi.ru
Address: Federal State Budgetary Scientific Institution «Federal Center for Toxicological, Radiation and Biological safety», Kazan, Russia 
Abstract. The article presents the results of studies on obtaining an erythrocyte diagnosticum for the indication of specific antibodies to Cl perfringens in IHA. Sheep erythrocytes were used as a cellular basis for the preparation of the diagnosticum. At the beginning, they were treated with formalin and tannin at a temper- ature of (37 ± 1) °C. Then they were sensitized with a mixture of toxoids and somatic antigens of 5 serotypes 39
of Cl perfringens (A, B, C, D, E), taken in equal volumes. Sensitization was carried out in a water bath at a temperature of (37 ± 1) °C, with continuous stirring for 2 hours. Then the sensitized erythrocytes were washed three times with phosphate-buffered saline solution (pH 7.2) and resuspended in the same solution up to 3 % concentration. The resulting erythrocyte diagnosticum was preserved with formalin to 1 % of the final concen- tration. The activity and specificity of the obtained erythrocyte antigen diagnosticum was determined by stag- ing IHA with control (negative and positive to Cl. perfringens) and heterologous (hyperimmune sera to Esch- erichia coli, Moraxella bovis) sera. A technique for staging IHA was developed to determine specific antibod- ies to the bacteria Cl. perfringens.
Keywords: Keywords: anaerobic enterotoxemia, Cl. perfringens, IHA, erythrocyte diagnosticum, calves
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Authors: Sergey Yurievich Smolentsev, doctor of veterinary sciences, Smolentsev82@mail.ru
Address: Mari State University, Yoshkar-Ola, Russia
Abstract. The greatest interest in the production of feed is caused by technologies that allow us to produce higher-quality feed while reducing their cost. Over the past decade, along with premixes, vitamins and dietary supplements, the animal feed diet has been replenished with algae. These include chlorella, a rep- resentative of green microscopic algae. It is advisable to use single-celled chlorella algae as a dietary supple- ment. The aim of the research was to study the effect of chlorella suspension and Bacillus subtilis 2336 com- bined on blood parameters of dairy goats. We used goats of the Zaanen breed in the experiment. The research was conducted in the conditions of a goat farm of the Lukoz agroholding in the Sernursky district of the Re- public of Mari El. According to the principle of analogues, 3 groups of milking goats with 20 heads each were formed. One of them was a control, the second and third acted as experimental ones. The main feed for goats is mixed grass hay, which is also accompanied by mineral-type additives, combined feeds. Goats belonging to the experimental groups received daily Algavet feed additive with water at the rate of 40 ml per animal. The 27
third group additionally received Bacillus subtilis 2336 in an amount of 105 CFU/ml. The experiment lasted for three months. The study showed that the clinical, physiological and hematological parameters of female goats from the experimental groups did not exceed the limits of physiological norms. At the end of the exper- iment, an increase in the number of erythrocytes and hemoglobin in the blood of the goats of the experimental groups was found compared with the control. The number of red blood cells increased by 3.20% and 8.20%, and the hemoglobin level increased by 2.50% and 5.59%, respectively. In addition, an increase in the content of total protein and albumins was also observed in the blood serum of the experimental groups of female goats. Total protein increased by 2.83% and 6.32%, and albumins increased by 3.80% and 9.11%, respectively.
Keywords: Keywords: goats, chlorella, blood, research, analysis of indicators, probiotic
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Authors: Liliyà I. Almitova, almitova.voda@mail.ru Venera I. Makaeva, v.makaeva@yandex.ru
Address: Federal State Budgetary Scientific Institution «Federal Center for Toxicological, Radiation and Biological safety», Kazan, Russia 
Abstract: Abstract. Nowadays, as a result of the ever-increasing anthropogenic impact on the environment, the water problem is especially acute: it is important to provide the population with high-quality drinking water. Springs are natural sources and have long been used as a source of drinking water. They are of great economic, recreational, cultural and historical importance. To date, the groundwater of the springs is used mainly by residents of small settlements and vacationer in the summer. The population associates such water with environmentally friendly and healthy water. However, the quality of natural water in urbanized areas has deteriorated significantly in recent decades. Drinking water from a local source of water supply in terms of chemical composition and properties must comply with the standards from SanPiN 1.2.3685-21. The article presents water monitoring data from the Apakai spring in the village of Lenino-Kokushkino, Pestrichinsky district of the Republic of Tatarstan in the summer of 2020 and 2023 in terms of organoleptic and chemical indicators. Given that the composition of drinking water is an important environmental factor affecting human health, the purpose of this work is to study the problem of water safety of sources of non-centralized drinking water supply of the population. It was revealed that the water in the spring does not meet the sanitary and hygienic requirements for water quality in terms of nitrates and the content of hardness salts. The content of nitrates exceeding the maximum permissible concentration in 2.32 times creates a public health risk. In this regard, it is necessary to continue to monitor the quality of water and continue to inform the population about its unsuitability for use.
Keywords: Keywords: springs, water quality, chemical indicators, maximum permissible concentration (MÐC), ni- trates, total hardness.
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Authors: Emil K. Rakhmatullin, doctor of veterinary sciences, amil59@yandex.ru Ilnur R. Kadikov, doctor of biological sciences, cir6@yandex.ru Nikolai M. Vasilevsky, doctor of veterinary sciences, vnickm@list.ru Ekaterina I. Kurshakova, candidate of biological sciences, keter-89@mail.ru Svetlana N. Potapova, candidate of veterinary sciences, svetlana150895@yandex.ru
Address: Federal State Budgetary Scientific Institution «Federal Center for Toxicological, Radiation and Biological safety», Kazan, Russia 
Abstract: Abstract. With the intensive animal husbandry, to realize the potential of animal productivity, feed additives with sorbing and probiotic properties are used. The research of the mechanism of hepatotoxic action of feed additives remains a poorly studied area of toxicology and veterinary clinical pharmacology. The hepa- totoxic effect of the Bisolbi feed additive was studied. Changes in biochemical parameters indicate the active participation of the liver in the metabolism of the feed additive. Dogs were given oral doses of Bisolbi feed additive at a dose of 0,5 g/kg for 31 days. It has been established that it, does not adversely affect the condition and behavior of animals, blood biochemical parameters, and it does not have a hepatotoxic effect.
Keywords: Keywords: feed additive, Bisolbi, blood biochemical parameters, hepatotoxic effect
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