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¹ 5, 2023

Ńźą÷ąņü ķīģåš ęóšķąėą ā ōīšģąņå .pdf (10,37 ĢĮ)
  VETERINARY PHARMACOLOGY WITH TOXICOLOGY
   
Title:

Feline Idiopathic Cystitis: Problems of Diagnosis and Therapy

   
Authors: Vladimir I. Gerunov, Taras V. Gerunov,
   
Address: Omsk State Agrarian University named after P.A. Stolypin, Omsk, Russia
   
Abstract:

Feline idiopathic cystitis is a widespread disease, and its pathogenesis has not been fully studied yet. This disease is often triggered by stress. The situation is often exacerbated by the presence of concomitant disorders of other organs and systems. For this reason, it is difficult to diagnose the disease. The diagnostics is based on the exclusion of other pathological conditions, for example, urolithiasis, bacterial cystitis, neoplasms, etc. The results of laboratory tests for this disease are not informative enough. Some authors suggest using proinflammatory cytokines, FMS-like tyrosine kinase 3 ligand (Flt3L), fibronectin, etc. as biomarkers. Analgesics, antidepressants, anticholinergics, antispasmodics, glycosaminoglycans, glucocorticoids, nonsteroidal anti-inflammatory drugs, drugs containing pheromones, etc. are used in treatment of animals with idiopathic cystitis. When prescribing diet therapy, special attention is paid to ensuring increased water consumption by an animal. To ensure comprehensive treatment, it is necessary to minimize anxiety and stress. In further studies, it is necessary to prove the specificity and sensitivity of the alleged biomarkers of the disease, to obtain convincing evidence of the effectiveness and safety of the drugs used for pharmacorrection, and to improve knowledge of the disease pathogenesis.

   
Keywords: feline idiopathic cystitis, Pandora syndrome, stress, pathogenesis, biomarkers, treatment, nutrition, multimodal environmental modification, diet therapy
   
References:

1.                  Letkin, A. I. Jeffektivnost' antistressovoj terapii pri idiopaticheskom cistite koshek / A. I. Letkin, E. N. Bikeeva // Vestnik AGAU. – 2022. – ¹ 5 (211). – S. 90-95.

2.                  Piskunova, O.G. Aktual'nye voprosy terapii idiopaticheskogo cistita koshek / O. G. Piskunova // Vestnik OrelGAU. – 2021. – ¹ 6 (93). – S. 44-47.

3.                  Sedoshkina, K. A. Sindrom Pandory u koshek / K. A. Sedoshkina, S. V. Filioglo // Bjulleten' nauki i praktiki. – 2019. – T.5., ¹ 4. – S. 240-244.

4.                  Sobolev, V. E. Idiopaticheskij cistit koshek / V. E. Sobolev // Rossijskij veterinarnyj zhurnal. Melkie domashnie i dikie zhivotnye. – 2012. – ¹ 2. – S. 47-51.

5.                  A case of recurrent feline idiopathic cystitis: the control of clinical signs with behavior therapy / A. Seawright, R. Casey, J. Kiddie Chew [et al.] // J Vet Behav. – 2008. – Vol. 3. P. 32–38. doi: 10.1016/j.jveb.2007.09.008.

6.                  Buffington, C. A. Idiopathic cystitis in domestic cats-beyond the lower urinary tract / C. A.  Buffington // J Vet Intern Med. – 2011. Vol. 25, ¹ 4. – P. 784-796. doi: 10.1111/j.1939-1676.2011.0732.x.

7.                  Buffington, C. A. T. Management of non-obstructive idiopathic/interstitial cystitis in cats / C. A. T. Buffington, D. J.  Chew // In Elliott J. A., Grauer G. F. (eds): BSAVA Manual of Canine and Feline Nephrology and Urology, 2nd ed. Gloucester, UK: British Small Animal Veterinary Association. – 2007. – P. 264.

8.                  Buffington, C.A.T. From FUS to Pandora syndrome: where are we, how did we get here, and where to now? / C. A. T. Buffington, J. L. Westropp, D. J. Chew // J Feline Med Surg. – 2014. Vol. 16, ¹ 5. – P. 385-394. doi: 10.1177/1098612X14530212.

9.                  Causes of lower urinary tract disease in Norwegian cats / B. K. Sævik, C. Trangerud, N. Ottesen [et al.] // J Feline Med Surg. – 2011. – Vol. 13, ¹ 6. – P. 410-417. doi: 10.1016/j.jfms.2010.12.012.

10.              Chadwin, R. M. Effect of a synthetic feline facial pheromone product on stress scores and incidence of upper respiratory tract infection in shelter cats / R. M. Chadwin, M. J. Bain, P. H. Kass // J Am Vet Med Assoc. 2017. – Vol. 251, ¹ 4. – P. 413-420. doi: 10.2460/javma.251.4.413.

11.              Chew, D. J. Nonobstructive Idiopathic or Interstitial Cystitis in Cats / D. J. Chew, S. P. DiBartola, P. A. Schenck // Canine and Feline Nephrology and Urology, 2nd ed. Philadelphia, USA: Saunders. – 2011. – P. 306–340. doi:10.1016/b978-0-7216-8178-8.10010-7.

12.              Chew, D. Pandora syndrome: it’s more than just the bladder / D. Chew, C. A. T. Buffington // Proceedings of the American Association of Feline Practitioners, Dallas, USA. – 2013. – P. 75e83.

13.              Clinical evaluation of multimodal environmental modification (MEMO) in the management of cats with idiopathic cystitis / C. A. Buffington, J. L. Westropp, D. J. Chew [et al.] // J Feline Med Surg. – 2006. – Vol. 8, ¹ 4. – P. 261-268. doi: 10.1016/j.jfms.2006.02.002.

14.              Comparison of foods with differing nutritional profiles for long-term management of acute nonobstructive idiopathic cystitis in cats / J. M. Kruger, J. P. Lulich, J. MacLeay [et al.] // J Am Vet Med Assoc. – 2015. – Vol. 247, ¹ 5 – P. 508-517. doi: 10.2460/javma.247.5.508.

15.              Comparison of urine protein profiles in cats without urinary tract disease and cats with idiopathic cystitis, bacterial urinary tract infection, or urolithiasis / S. I. Lemberger, C. A. Deeg, S. M. Hauck [et al.]  // Am J Vet Res. – 2011. – Vol. 72, ¹ 10. – P. 1407-1415. doi: 10.2460/ajvr.72.10.1407.

16.              Dowers, K. Updates in feline medicine / K. Dowers // Adv Small Anim Med Surg. – 2012. – Vol. 25. – P. 1–4. doi: 10.1016/j.asams.2012.04.001.

17.              Dru Forrester, S. Evidence-based management of feline lower urinary tract disease / S. Dru Forrester, P. Roudebush // Vet Clin North Am Small Anim Pract. – 2007. - Vol. 37, ¹ 3. – P. 533-558. doi: 10.1016/j.cvsm.2007.01.009.

18.              Dyer, A. J. Painful bladder syndrome: an update and review of current management strategies / A. J. Dyer, C. O. Twiss // Curr Urol Rep. – 2014. – Vol. 15, ¹ 2. – P. 384. doi: 10.1007/s11934-013-0384-z.

19.              Effects of Waiting Room and Feline Facial Pheromone Experience on Blood Pressure in Cats / L. R. Van Vertloo, J. M. Carnevale, R. L. Parsons [et al.] // Front Vet Sci. – 2021. – Vol. 8. – P. 640751. doi: 10.3389/fvets.2021.640751.

20.              Evaluation of the efficacy of an appeasing pheromone diffuser product vs placebo for management of feline aggression in multi-cat households: a pilot study / T. L. DePorter, D. L. Bledsoe, A. Beck [et al.]  // J Feline Med Surg. – 2019. - Vol. 21, ¹ 4. – P. 293-305. doi: 10.1177/1098612X18774437.

21.              Feline Idiopathic Cystitis: Pathogenesis, Histopathology and Comparative Potential / E. Jones, C. Palmieri, M. Thompson [et al.] // J Comp Pathol. – 2021. – Vol. 185. – P. 18-29. doi: 10.1016/j.jcpa.2021.03.006.

22.              Feline Uroepithelial Cell Culture as a Novel Model of Idiopathic Cystitis: Investigations on the Effects of Norepinephrine on Inflammatory Response, Oxidative Stress, and Barrier Function / P. Hatala, A. Lajos, M. Mackei [et al.]  // Vet Sci. – 2023. – Vol. 10, ¹ 2. – P. 132. doi: 10.3390/vetsci10020132.

23.              Forrester, S.D. Feline idiopathic cystitis / S. D. Forrester, T. L.  Towell // Vet Clin North Am Small Anim Pract. – 2015. – Vol. 45, ¹ 4. – P. 783-806. doi: 10.1016/j.cvsm.2015.02.007.

24.              Frank, D. Systematic review of the use of pheromones for treatment of undesirable behavior in cats and dogs / D. Frank, G. Beauchamp, C. Palestrini // J Am Vet Med Assoc. – 2010. - Vol. 236, ¹ 12. – P. 1308-16. doi: 10.2460/javma.236.12.1308.

25.              Griffith, C.A. Effects of a synthetic facial pheromone on behavior of cats / C. A. Griffith, E. S. Steigerwald, C. A. Buffington // J Am Vet Med Assoc. – 2000. - Vol. 217, ¹ 8. – P. 1154-1556. doi: 10.2460/javma.2000.217.1154.

26.              Gunn-Moore, D. Feline lower urinary tract disease / D.  Gunn-Moore // J Feline Med Surg. – 2003. – Vol. 5, ¹ 2. – P. 133-138. doi: 10.1016/S1098-612X(02)00129-8.

27.              Inflammation and Tissue Remodeling in the Bladder and Urethra in Feline Interstitial Cystitis / F. A. Kullmann, B. M. McDonnell, A. S. Wolf-Johnston [et al.] // Front Syst Neurosci. – 2018. – Vol. 12. – P. 13. doi: 10.3389/fnsys. Kullmann 2018.00013.

28.              Kruger, J.M. Changing paradigms of feline idiopathic cystitis / J. M. Kruger, C. A. Osborne, J. P.  Lulich // Vet Clin North Am Small Anim Pract. – 2009. Vol. 39, ¹ 1. – P. 15-40. doi: 10.1016/j.cvsm.2008.09.008. PMID: 19038648.

29.              Kwon, W. A. Animal Model of Interstitial Cystitis/Bladder Pain Syndrome / W. A. Kwon // Int Neurourol J. – 2018. – Vol. 22(Suppl. 1). – P. 1-2. doi: 10.5213/inj.1820edi.001.

30.              Parys, M. Serum Cytokine Profiling in Cats with Acute Idiopathic Cystitis / M. Parys, V. Yuzbasiyan-Gurkan, J. M. Kruger // J Vet Intern Med. – 2018. – Vol. 32, ¹ 1. – P. 274-279. doi: 10.1111/jvim.15032.

31.              Prevalence, Risk Factors, Pathophysiology, Potential Biomarkers and Management of Feline Idiopathic Cystitis: An Update Review / C. He, K. Fan, Z. Hao [et al.] // Front Vet Sci. – 2022. Vol. 9. – P. 900847. doi: 10.3389/fvets.2022.900847.

32.              Shu, H. Effect of a synthetic feline facial pheromone product on stress during transport in domestic cats: a randomised controlled pilot study / H. Shu, X. Gu // J Feline Med Surg. – 2022. – Vol. 24, ¹ 8. – P. 691-699. doi: 10.1177/1098612X211041305.