Our address:
Federal Center for Toxicological, Radiation, and Biological Safety - All Russian Research Veterinary Institute, 2-Nauchny gorodok, Kazan, 420075, Russia

Tel. / Fax:(843) 239-53-20 (editorial)

E-mail: vetvrach@vnivi.ru

The journal is registered

The journal is registered in Federal Service for Oversight of Mass Media, Telecommunications, and Protection of Cultural Heritage.

The Registration Certificate number is 77-29757 

Decision of the Presidium

of the Russian Higher Attestation Committee

The Veterinarny Vrach journal is one of the Russian peer-viewed research journals eligible to publish main research findings and results of theses pending a scientific degree of Doctor or Cadidate of Sciences.

Archive

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

2022

2023

4, 2023

.pdf (12,89 )
  VETERINARY PHARMACOLOGY WITH TOXICOLOGY
   
Title:

Pharmacological effect of injectable forms of copper and cobalt nanopowders on morpho-biochemical parameters of blood of cows

   
Authors: Vladimir V. Zaitsev 1, Nikolai A. Pudovkin 2, Petr V.Smutnev 2, Natalya I. Zakharkina 1, Dmitry V. Vorobyov1
   
Address:
1 Astrakhan State University named after V.N. Tatishchev, Astrakhan, Russia
2Saratov State University of Genetics, Biotechnology and Engineering named after N.I. Vavilova, Saratov, Russia
   
Abstract: Currently, the problem of good nutrition and a balanced diet for farm animals is one of the leading ones, since their productivity and economic performance of the agricultural segment directly depend on this. Biologically active supplements containing vitamin-mineral complexes play an important role in solving this problem. Mineral substances in the animal body are involved in the processes of digestion, synthesis and decomposition of macromolecular compounds. At the same time, not only the total content of such substances in the diet is of great importance, but also the availability of micro- and macroelements, as well as their assimilation by the animal organism. The aim of our research was to determine the effect of injection forms of copper and cobalt nanopowders on hematological and some biochemical parameters of cow blood. The conducted studies made it possible to evaluate the effectiveness of injectable forms of mineral compounds based on copper and cobalt for the implementation of therapeutic and preventive measures for hypomicroelementosis in animals. It was found that the use of the drug for 10 days did not significantly change the hematological parameters of the blood of cows. It has been determined that the subcutaneous administration of the mineral complex of copper and cobalt does not significantly change the leukocyte formula of the blood of experimental animals. Studies have shown that after intramuscular administration of a nanopreparation based on copper and cobalt, there is a significant increase in the blood serum activity of a number of enzymes, such as lactate dehydrogenase, as well as some metabolites, in particular, glucose. The use of the studied preparations will make it possible to use them more widely both for the treatment and prevention of endemic diseases and diseases of metabolic disorders, both in productive and unproductive animals.
   
Keywords: copper, cobalt, microelement, enzyme, blood, cow
   
References:

1. Alekseeva, L. V. The concentration of bioelements in the blood of Hereford bulls when copper is introduced into the diet in various forms / L. V. Alekseeva, N. A. Lukyanova, A. A. Lukyanov // Zootechnics. 2017. No 1. P. 1518.

2. Investigation of intestinal microbiocinosis in rats in response to the command of copper and zinc nanoparticles to their diet / E. S. Aleshina, E. A. Drozdova, E. I. Tarasova, I. A. Gavrish // Trace elements in medicine. 2019. Vol. 20, No 1. . 1320.

3. Byshova, D. N. Influence of metal nanopowders on the physiological parameters of animals / D. N. Byshova, L. E. Ampleeva, S. D. Polishchuk // In the collection: Youth and the XXI century 2022 : Materials of the 12th International Youth Scientific Conference. Kursk, 2022. P. 275278.

4. Carbohydrate metabolism and milk productivity of Holstein cows with the introduction of cobalt nanopowder into the diet / P. M. Makarov, I. A. Stepanova, A. A. Nazarova, S. D. Polishchuk // Zootechnics. 2017. No 6. . 2528.

5. Mamedov, E. F. Changes in carbohydrate, protein and lipid metabolism in mice with oral administration of manganese nanopowder / E. F. Mammadov // Bulletin of Medical Internet Conferences. 2015. Vol. 5, No 5. . 504.

6. Features of the mineral metabolism of Holstein heifers with the introduction of cobalt nanopowder into the diet / I. A. Stepanova, A. A. Nazarova, S. D. Polishchuk // Veterinary medicine, zootechnics and biotechnology. 2017. No 6. . 117122.

7. Effect of multiple administration of copper nanoparticles on the elemental composition of rat liver / E. A. Sizova, S. A. Miroshnikov, S. V. Lebedev., N. N. Glushchenko // Bulletin of the Orenburg State University. 2012. No 6. . 13.

8. Chkalova, M. V. Prospects for the use of ultrafine components in the industrial production of combined feeds / M. V. Chkalova, V. D. Pavlidis // Equipment and technologies in animal husbandry. 2022. No 2 (46). . 9397.

9. The role of biological products based on nanodispersed metal powders in animal husbandry / V. V. Churilova, D. G. Churilov, S. D. Polishchuk, G. I.Churilov // In the collection: Innovative potential of the development of society: the view of young scientists. Collection of scientific articles of the 2nd All-Russian scientific conference of advanced developments. Kursk, 2021. . 282287.

10. Physiological and biochemical parameters of Holstein heifers when adding to their diet bio-drugs containing cuprum and cobalt nanoparticles / P. M. Makarov, I. A. Stepanova, A. A. Nazarova, S. D. Polishchuk, G. I. Churilov // Nano Hybrids and Composites. 2017. Vol. 13. . 123129.

11. Influence of copper nanopowder on parameters of carbohydrate and lipid metabolism of Holstein heifers / A. A. Nazarova, I. A. Stepanova, S. D. Polischuk., V. V.Churilova, G. I.Churilov, D. G.Churilov // International Journal of Nanotechnology. 2019. Vol. 16, No 1-3. . 122132.