Our address:
Federal Center for Toxicological, Radiation, and Biological Safety - All Russian Research Veterinary Institute, 2-Nauchny gorodok, Kazan, 420075, Russia

Tel. / Fax:(843) 239-53-20 (editorial)

E-mail: vetvrach@vnivi.ru

The journal is registered

The journal is registered in Federal Service for Oversight of Mass Media, Telecommunications, and Protection of Cultural Heritage.

The Registration Certificate number is 77-29757 

Decision of the Presidium

of the Russian Higher Attestation Committee

The Veterinarny Vrach journal is one of the Russian peer-viewed research journals eligible to publish main research findings and results of theses pending a scientific degree of Doctor or Cadidate of Sciences.

Archive

2010

2011

2012

2013

2014

2015

2016

2017

2018

2019

2020

2021

2022

2023

3, 2023

.pdf (11,52 )
  VETERINARY PHARMACOLOGY WITH TOXICOLOGY
   
Title:

Effect of T-2 toxin and zearalenone on the content of heat shock proteins in primary liver cell cultures

   
Authors: Andrey I. Samsonov, Alsu R. Makaeva, Rishat S. Mukhammadiev, Linar R. Valiullin, Zhanna R. Nasybullina
   
Address:

Federal State Budgetary Scientific Institution Federal Center for Toxicological, Radiation and Biological safety, Kazan, Russia

   
Abstract:

Contamination of food and feed with mycotoxins is of exceptional importance worldwide. In natural conditions, combined contamination of mycotoxins is more common. Toxin T-2 is one of the most dangerous agent of the group of trichothecene mycotoxins. At the cellular level, one of the main harmful effects of the T-2 toxin is the primary inhibition of protein synthesis due to binding of the peptidyltransferase enzyme and disruption of translation directed to the 60S ribosomal subunit. In addition, the presence of the toxin can lead to disorders at the genetic level, such as the induction of DNA fragmentation or DNA damage. Data on the effect of trichothecenes on the expression of the HSP70 heat shock protein gene are limited. In this regard, the aim of the study was to study the effect of T-2 toxin and zearalenone on the content of heat shock proteins in primary chicken liver cell cultures. To do this, the cell suspension was poured into glass vials of 2 cm3 each. T-2 toxin and zearalenone were introduced into vials in the form of an alcohol solution of 0.001 cm3 at doses of 0; 10; 100 and 1000 nM/m3. Vials with cellular suspension into which ethyl alcohol (96 vol. %) 0.001 cm3 was introduced were used as control. Subsequently, the vials were incubated at a temperature of 37 C for 24 hours. Then a dispersing solution was introduced in a volume of 0.2 cm3 per vial and incubated in a thermostat at 37 C for 20 minutes. The production of heat shock protein HSP70 was measured using ELISA. It was found that the introduction of zearalenone slightly changed the content of HSP70, the introduction of T-2 toxin, depending on the dose, caused an increase in the protein content up to 70 %, and the combined introduction of mycotoxins increased the protein content of heat shock by 180 %, which indicates a synergistic effect, however, the mechanisms of the effect require additional research.

   
Keywords: T-2 toxin, zearalenone, primary liver cell culture, heat shock proteins
   
References:

1.    Kępińska-Pacelik J, Biel W. Alimentary Risk of Mycotoxins for Humans and Animals. Toxins (Basel). 2021. No 21, 13(11). P. 822. DOI: 10.3390/toxins13110822.

2.    Mycological assessment of feed in the Republic of Tatarstan / R. . Potekhina, . . Ermolaeva, Z. Kh. Sagdeeva, E. I. Semenov // The Veterinarian. 2019. 1. P. 1923.

3.    Infestation of fungi with fungi of the genus Fusarium / . . Ermolaeva, R. . Potekhina, L. . Matrosova, E. I. Semenov // Scientific notes Kazan Bauman state academy of veterinary medicine. 2019. Vol. 239, No 3 P. 121124.

4.    Semenova, S. A. Study of the antagonism of microscopic fungi to pathogenic microbes / S. A. Semenova, E. A. Magdeeva, . . Galiullin // Advances in medical mycology. 2014. Vol. 12. P. 339341.

5.    Search for antagonists in relation to sanitary-indicative microbes / S. A.Semenova, Yu. V. Krasovskaya, P. V. Sofronov, F. M. Nurgaliev // Vestnik of the Mari State University. Chapter Agriculture. Economics. 2022. Vol. 8, 1 (29). P. 6371.

6.    Occurrence and Co-Occurrence of Mycotoxins in Cereal-Based Feed and Food / R Palumbo, . Crisci, . Venâncio [et al.] // Microorganisms. 2020. Vol. 3;8(1). P. 74. DOI: 10.3390/microorganisms8010074.

7.    Prevention of mycotoxicosis in minks with the use of shungite and hitinglucans / A.I. Samsonov, N.M. Vasilevsky, Zh. R. Nasybullina, I. M. Fitsev // Krolokovodstvo i Zverovodstvo. 2022. 5. P. 4349.

8.    Semenov, E. I. Combined effects of T-2 toxin, deoxynivalenol and zearalenone / E. I. Semenov // Advances in medical mycology. 2015. Vol. 14. P. 302306.

9.    The combined effects of mycotoxins on physiological parameters in rats / L. R. Valiullin, D. D. Khayrullin, E. I. Semenov [etc.] // Scientific notes Kazan Bauman state academy of veterinary medicine. 2015. Vol. 221, 1. P. 45-48.

10.     Combined animal lesions and the development of prevention and treatment tools: monograph / . Kh. Papunidi, G. V. Konukhov, R. N. Nizamov [et al.]. Kazan : FSBSI FCTRBS-ARRVI, 2019. 248 p.

11.     Samsonov, A. I. Prevention of T-2 toxicosis in minks / A. I. Samsonov, V. N. Dervyanov // The Veterinarian. 2007. 2. P. 1718.

12.     Pharmaco-toxicological reason for introduction of inorganic and organic sorbents combination to animal diet at T-2 toxicosis / N. N. Mishina, E. I. Semenov, . Kh. Papunidi [etc.]. The Veterinarian. 2019. 2. P. 3037.

13.     Analytics of T-2 toxin distribution data in the republic of Tatarstan / I. N. Shtyrov, E. I. Semenov, L. . Matrosova [et al.]. // International bulletin of Veterinary. 2021. 1. P. 167172.

14.     Toxicity evaluation of fodder from various regions of the Russian Federation / S. A.Semenova, R. . Potekhina, E. I. Semenov [etc.] // Scientific notes Kazan Bauman state academy of veterinary medicine. 2015. Vol. 224. 4. P. 196199.

15.     Cases of mass poisoning of animals, birds and fish some regions of the russian federation and the cis countries / E. I. Semenov, . . Tremasova, L. . Matrosova [etc.] // Veterinary medicine. 2021. 8. P. 3944.

16.     Valiev, . R. Immunosuppression in the pathogenesis of T-2 mycotoxicosis and its pharmacocorrection / . R. Valiev, E. I. Semenov, F. G. Akhmetov // The Veterinarian. 2011. 2. P. 46.

17.     Screening drugs-potential immunomodulators for T-2 mycotoxicosis / E.I. Semenov, N. N. Mishina, I.R. Kadikov [et al.] // Bali Medical Journal. 2017. No 6(2). . 110114. DOI:10.15562/bmj. v6i2.516.

18.     Gastric ulcer in pigs and changes in the number of bacteria of the genus Helicobacter under the mycotoxins influence / F.M. Nurgaliev, E. I. Semenov, O.K. Pozdeev, P.V. Sofronov // The Veterinarian. 2020. 2. P. 3138.

19.     Evaluation of the protective effect of the developed preventive complexes on DNA integrity in experimental combined mycotoxicosis / . Yu. Tarasova, N. I. Khammadov, L. . Matrosova, . . Osyanin // The Veterinarian. 2022. 4. P. 70-76.

20.     Ivanov,

   
   
Title:

Study of acute toxicity of the liquid feed additive "Active Mix" VMG in experiments on rats.

   
Authors: Andrey N. Kulikov1, Alexander V. Shishkin2, Roman O. Vasiliev3, Marina S. Kulikova1, Ekaterina A. Mikheeva1
   
Address:

1Udmurt State Agrarian University Izhevsk, Russia

2Production company Izhsintez- Khimprom, Izhevsk, Russia

3St. Petersburg State University of Veterinary Medicine, St. Petersburg, Russia, secretary@spbguvm.ru

   
Abstract: When creating a liquid vitamin and mineral feed additive Active Mix VMG 500/600, a number of new solutions were used, aimed both at increasing the digestibility of vitamins and trace element compounds, and at reducing the toxicity of some of them. This feed additive consists of 2 parts (liquids) Active Mix VMG-500 and Active Mix VMG-600, which are given to animals separately. The article presents the results of a study of their acute toxicity during intragastric administration to laboratory rats, on the basis of which these liquids can be classified as low-hazard drugs (4th hazard class in accordance with GOST 12.1.007-76).
   
Keywords: trace elements, chelated complex compounds, vitamins, feed additive, acute toxicity, rats
   
References:

1. Veterinary and sanitary assessment of goat meat when using UVMC Vita-balance / R. A. Asrutdinova, D. D. Khairullin, Sh. K. Shakirov, I. R. Kadikov, I. F. Vafin, L. A. Rakhmatov // Scientific notes of the Kazan State Academy of Veterinary Medicine named after N. E. Bauman. 2021. Vol. 248, No 4. . 15-18.

2. Belenky, M. L. Elements of quantitative assessment of pharmacological effect. L. : Medgiz, 1972 151 p.

3. Microstructure of the liver of mice against the background of the introduction of various doses of premix mix / D. S. Berestov, A. V. Shishkin, E. I. Troshin, Yu. G. Vasiliev, D. I. Krasnoperov // International Bulletin of Veterinary Medicine. 2018. No 4. . 129-134.

4. Indicators of acute toxicity of DAPS-25k in mice with intragastric administration / R. O. Vasiliev, E. I. Troshin, N. Yu. Yugatova [et al.] // Issues of regulatory regulation in veterinary medicine. 2020. No 1. . 241-245.

5. Functional activity of the thyroid gland of rats with acute radiation damage against the background of the use of liquid feed additive ActiveMix VMG-500 / R. O. Vasiliev, A. V. Shishkin, A. N. Kulikov [et al.] // he Veterinarian. 2022. No 4. . 7-15.

6. Methodological recommendations on the maintenance of laboratory animals in vivariums of research institutes and educational institutions / P. N. Vinogradov, S. S. Shevchenko, O. L. Sedov, E. S. Garafutdinova, M. F. Malygin //: RD - APK 3.10.07.02-0. Giproniselkhoz. 2009. . 12-15.

7. Izmailov, E. Organic forms of trace elements. The topic does not lose relevance! / E. Izmailov // Effective animal husbandry. 2021. 9 (175). . 13-18.

8. Keller, S. Chelated trace elements: the right choice / S. Keller, F. Bul, M. Kuipers //Animal Husbandry of Russia. 2020. No 3. . 14-18.

9. Lyutykh, O. The great role of trace elements / O. Lyutykh // Efficient animal husbandry. 2020. 4 (161). . 95-99.

10. Guidelines for conducting preclinical studies of medicines. Part one. M. : Vulture and K, 2012. 944 p.

11. Rusin, V. I. The influence of inorganic and organic compounds of trace elements on their level in the blood serum of dairy cows / V. I. Rusin // Scientific notes of the educational institution Vitebsk Order of the Badge of Honor State Academy of Veterinary Medicine. 2018. Vol. 54, No 1. . 46-49.

12. Telkova, O. L. The influence of the premix "vita prem" on the health and productivity of young pigs / O. L. Telkova // In the collection: Agriculture - problems and prospects. collection of scientific papers. Grodno. 2020. . 242-255.

13. Ushakova, T. M. An adequate criterion for the diagnosis of microelementosis in cattle in the mother-offspring system / T. M. Ushakova, E. A. Starikova // International Bulletin of Veterinary Medicine. 2019. No 1. . 140-148.

14. Falina, Yu. O. Feed additive with iron group bioelements/ Yu. O. Falina // In the collection: Innovations in Modern Science : materials of the International (correspondence) scientific and practical conference. Neftekamsk, 2021. . 19-22.

15. Khairullin, D. D. Veterinary and sanitary examination of sheep meat and the content of heavy metals in it when using a modern feed additive / D. D. Khairullin, Sh. K. Shakirov, I. R. Kadikov, I. F. Vafin, R. A. Asrutdinova, G. S. Sharafutdinov // Scientific notes of the Kazan State Academy of Veterinary Medicine named after N. E. Bauman. 2021. Vol. 248, No 4.   . 268-271.

16. Vasiliev, R. O. Assessment of the toxicological parameters of DAPS-25k after a single intragastric administration to mice and guinea pigs / R. O. Vasiliev, E. I. Troshin, S. A. Brevnova, N. Yu.  Yugatova, A. V. Shishkin, I. L. Vasilyeva, A. N. Kulikov // International Transaction Journal of Engineering, Management and applied sciences and technologies. 2020. Vol. 11, No 10. P. 11A10.

   
   
Title:

Assessment of mutagenic activity of a biological product based on lactic acid and propionic acid microorganisms in vivo

   
Authors: Rint S. Mukhammadiev, Rishat S. Mukhammadiev, Lenar R. Valiullin, Rifkat R. Musin, Anna M. Tremasova
   
Address:

Federal State Budgetary Scientific Institution Federal Center for Toxicological, Radiation and Biological safety, Kazan, Russia

   
Abstract: Lactic acid and propionic acid bacteria are widely used in various fields of industry, veterinary medicine, food and pharmaceutical industries. In order to obtain high-quality feed necessary to create optimal conditions for the development of normal microflora of the gastrointestinal tract of farm animals and birds and, thus, to increase the number of livestock, it is relevant to develop drugs based on a combination of these bacteria to improve the technology of canning and silage feed. At the same time, according to the World Health Organization, the European Food Safety Agency, drugs based on such consortia should not only be effective, but also safe. The mutagenic activity of a biological product based on lactic acid and propionic acid microorganisms was evaluated in vivo. The mutagenic activity of the drug developed by us based on strains of lactic acid and propionic acid microorganisms using the method of accounting for chromosome aberrations in mouse bone marrow cells did not reveal a statistically significant increase in the number of cells with structural chromosome disorders compared to the negative control group. The micronucleus test also showed no increase in the number of micronuclear erythrocytes in mice compared with the negative control group. The data obtained by the method of accounting for chromosome aberrations in mouse bone marrow cells are confirmed by the results obtained by the method of counting micronuclei in mammalian cells and indicate the safety of a biological product based on lactic and propionic acid microorganisms, as well as the possibility of its further use in agriculture and veterinary medicine.
   
Keywords: biological product, lactic acid, propionic acid bacteria, mutagenicity, in vivo
   
References:

1. Abilev, S. K. Accelerated methods for predicting mutagenic and blastomogenic properties of chemical compounds. Itogi Nauki i Tekhniki. Series Toxicology. Moscow : VINITI, 1986. Vol. 14. . 171.

2. Arefiev, V. A. English-Russian explanatory dictionary of genetic terms / V. A. Arefiev, L. A. Lisovenko. Moscow : VNIRO, 1995. 407 p.

3. Arifullina, L. R. onsortium of bacteria as a basis for the creation of probiotic supplements for animal husbandry / L. R. Arifullina, G. S. Volkova // Storage and processing of agricultural raw materials. 2018. No 1. P. 4145.

4. Influence of a probiotic preparation based on Bacillus subtilis on the microbial community of the intestines of rats / E. V. Skvortsov, R. S. Muhammadiev, R. S. Mukhammadiev [et al.] // Bulletin of Biotechnology and Physico-Chemical Biology Yu. A. Ovchinnikova. 2019. Vol. 15 (1). P. 3035.

5. Ivanov, D. V. Modern technologies and technical means of preparing ensiled feed: a textbook / D. V. Ivanov  Stavropol : Stavropol State Agrarian University, AGRUS, 2014. 44 p.

6. Study of the cytotoxicity of lactic acid and propionic acid bacteria in the in vitro test / Rin. S. Muhammadiev, Rish. S. Muhammadiev, E. V. Skvortsov [et al.] // The Veterinarian. 2019. No 4. P. 1720.

7. Probiotics based on living cultures of microorganisms / V. V. Smirnov, N. K. Kovalenko, B. C. Podgorsky [et al.] // Microbiological journal. 2002. Vol. 64, No 4. P. 6278.

8. Guidelines for the experimental (preclinical) study of new pharmacological substances / edited by V. P. Fisenko, E. V. Arzamastsev, E. A. Babayan Moscow : CJSC Remedium, 2000. 398 p.

9. Guidelines for short-term tests for the detection of mutagenic and carcinogenic chemicals: Environmental health criteria. Geneva : WHO, 1989. No 51. 212 p.

10. Modern bacteriological preparations: impact on the intestinal microbiota and the role in the treatment of diseases / K. V. Raskina, E. Yu. Martynova, I. R. Fatkhutdinov, Yu. E. Poteshkin // Russian medical journal 2018. Vol. 26, No 5 (2). P. 8191.

11. Fonshtein, L. M. Methods for the primary detection of the genetic activity of environmental pollutants using bacterial test systems / L. M. Fonshtein, S. K. Abilev, E. V. Bobrinev // Moscow : Higher School, 1985. 34 p.

12. Biodiversity, ecological determinants, and metabolic exploitation of sourdough microbiota / L. De Vuyst, G. Vrancken, F. Ravyts, T. Rimaux [et al.] // Food microbiology. 2009. Vol. 26 (7).        P. 666675.

13. Detection of carcinogens as mutagens in the Salmonella / microsome test: assay of 300 chemicals / J. McCann, E. Choi, E. Yamasaki [et al.] // Proceedings of the National Academy of Sciences. 1975. Vol. 72. P. 51355139.

14. Ford, C. E. Acolchicine, hypotonic citrate, squash sequence for mammalian chromosomes / C. E. Ford, J. L. Hamerton // Stain Technol. 1956. Vol. 31. . 247.

15. Giraffa, G. Importance of lactobacilli in food and feed biotechnology / G. Giraffa, N. Chanishvili, Y. Widyastuti // Research in microbiology. 2010. Vol. 161. P. 480487.

16. Oral administration of Lactobacillus plantarum strain AYA enhances IgA secretion and provides survival protection against influenza virus infection in mice / Y. Kikuchi, A. KunitohAsari, K. Hayakawa [et al.] // Public Library of Science. 2014. Vol. 9 (1). P. 19.

17. Preston, R. J. Mammalian in vivo Cytogenetic Assays: Analysis of Chromosome Aberrations in Bone Marrow Cells / R. J. Preston // Mutation Research. 1987. Vol. 189. P. 157165.

18. Sarowska, J. Thetherapeutic effect of probiotic bacteria on gastrointestinal diseases / J. Sarowska, I. Choroszy-Krol, B. Regulska-Ilow // Advances in Clinical and Experimental Medicine. 2013. Vol. 22 (5). P. 759766.

19. Takeda, K. Effects of a fermented milk drink containing Lactobacillus casei strain Shirota on the human NK cell activity / K. Takeda, K. Okumura // Journal of Nutrition. 2007. Vol. 137 (3). P. 791793.

20. Von Wright, A. Regulating the safety of probiotics the European approach / A. Von Wright // Current Pharmaceutical Design. 2005. Vol. 11. P. 123.

   
   
Title:

Reproductive qualities of repair pigs against the background of the use of immunotropic drugs

   
Authors: Alyona V. Kovalenko, Dmitry A. Nikitin, Vladimir G. Semenov, Lyubov P. Gladkikh, Lyudmila A. Semenova
   
Address:

Chuvash State Agrarian University, Cheboksary, Russia

   
Abstract: The purpose of this work is to realize the biopotential of reproductive qualities of repair pigs by immunocorrection of the body with PigStim-V and PigStim-F. For the experiment, 3 groups of 10 heads each were formed from 30 suckling pigs (pigs). Pigs of the 1st experimental group were injected intramuscularly with the immunotropic drug PigStim-V at a dose of 1 ml per head three times, on the 15th, 20th and 25th days of life. Pigs of the 2nd experimental group were injected with the immunotropic drug PigStim-F according to a similar scheme. The control group pigs were not injected with immunotropic drugs. Insemination of pigs was carried out in the 4th sexual hunt, at the age of 7.5-8.0 months and the optimal live weight. The positive effect of the immunotropic drugs PigStim-V and PigStim-F on the reproductive qualities of repair pigs was revealed. In animals of the 1st and 2nd experimental groups, there is a decrease in the age of manifestation of the first sexual hunt by 4.2 and 5.4 days, and the age of the first insemination by 4.0 and 5.8 days, and its fruitfulness increases. Against the background of immunocorrection of the body, the rate of multiple births increased by 6.78 and 10.17 %, and stillbirth decreased by 33.3 %. Immunotropic drugs helped to reduce the incidence of postpartum diseases in sows, such as metritis-mastitis-agalactia syndrome and increased the effectiveness of therapeutic measures to 100%. Against the background of the use of PigStim-V and PigStim-F for repair pigs, the safety of piglets obtained from them increased by 1.80 and 1.85 %, and the live weight at weaning was higher than the control values by 0.12 and 0.10 kg. The duration of the period from weaning to the onset of the next sexual hunt in sows of the 1st and 2nd experimental groups decreased by an average of 0.4 and 0.2 days.
   
Keywords: repair pigs, immunotropic drugs Pigs team-V and Pigs team-F, multiple pregnancy, metritis-mastitis-agalactia syndrome, preservation, live weight at weaning, nest weight, the period from weaning to insemination
   
References:

1. Gritsenko, S.A. The influence of microclimate in a room for sows on the reproductive qualities of animals / S. A. Gritsenko, E. G. Podugonnikova, A. S. Ulyanov // BIO. - Yekaterinburg, 2020. - 2 (233).

P.19-21.

2. Denisov, A.V. Etiological features of gastrointestinal diseases of young pigs in the conditions of an industrial complex /A.V. Denisov, A.A. Stepanov //Innovations in agriculture: Problems and prospects. - May, 2016. - 1 (9).- P. 92-96.

3. Dronov, V.V. Analysis of the morbidity of pigs associated with insufficient feeding in the farms of the Belgorod region / V.V. Dronov //Agrarian science at the beginning of the XXI century: mat. international scientific and practical conference of young scientists and specialists.- Voronezh, 2002.- p.4-6.

4. Ignatkin, I.Yu. Ventilation systems and the influence of microclimate parameters on the productivity of pigs / I. Yu. Ignatkin, M. G. Kuryachiy // Bulletin NGIEI.- Knyaginino, 2012.- 10 (17).- P.16-34.

5. Chertkov, D.D. The relationship of microclimate conditions with the productive qualities of pigs / D. D. Chertkov, A. A. Kretov, B. D. Chertkov [et al.] // Bulletin of the Don State Agrarian University.- Persianovsky, 2016.- 4 - 1 (22).- P.22-29.

   
   
Title:

In vitro characteristics of natural sorbents to a pesticide of the neonicotinoid class

   
Authors: Nailya N. Mishina, Damir V. Aleev, Guzaliya R. Yamalova, Kadria F. Khalikova, Gulnara G. Galyautdinova
   
Address:

Federal State Budgetary Scientific Institution Federal Center for Toxicological, Radiation and Biological safety, Kazan, Russia

   
Abstract: Contamination of feed with neonicotinoids in natural conditions is possible if plant treatment regimes are not observed, during harvesting, during storage and processing. While, getting into the food chain, the pesticide poses a serious threat to animal and human health. One of the ways to reduce the negative impact of various toxicants on the body is the use of additives with high sorption properties. In order to study the sorption properties, we selected zeolite and shungite. Zeolite is a widespread useful mineral that has sorption properties to various substances, enriches the body with trace elements and improves metabolism. Shungite is a carbon-containing rock with high mechanical strength, good filtering ability and the ability to sorb organic and mineral substances. Once in the body, shungite has an analgesic effect and bactericidal properties. The aim of our work was to study the features of the sorption of imidacloprid with sorbents shungite and zeolite and their combinations in vitro. As a result of the conducted studies, it was found that the sorbents showed the greatest adsorption capacity for imidacloprid in the following sequence: shungite 30 %, zeolite/shungite (30/70) 26 %, zeolite/shungite (50/50) 22 %, zeolite/shungite (70/30) 10.2 %, zeolite 6.6 %. Thus, sorbents shungite and its combination with zeolite (where the percentage of shungite is greater) have pronounced sorption properties with respect to imidacloprid, and are promising for further study in in vitro experiments with other neonictinoids.
   
Keywords: imidacloprid, adsorbent, zeolite, shungite, adsorption, desorption
   
References:

1. Chromatographic methods for determining pesticides from the group of neonicotinoids / D. V. Aleev, K. F. Khalikova, K. E. Burkin [et al.] // Scientific notes of the Kazan State Academy of Veterinary Medicine named after N. E. Bauman. 2019. Vol. 237, No 1. . 6-10. DOI 10.31588/2413-4201-1883-237-1-6-10.

2. Baskova, E. Y. The use of enterosorbents based on nanotechnology to combat mycotoxicosis of animals / E. Y. Baskova // Scientific notes of the Kazan State Academy of Veterinary Medicine named after N.E. Bauman. Kazan, 2008. Vol. 192. . 234236.

3. State catalog of pesticides and agrochemicals approved for use on the territory of the Russian Federation // Ministry of Agriculture of Russia. URL: https://mcx.gov.ru/ministry/departments/departament-rastenievodstva-mekhanizatsii-khimizatsii-i-zashchity-rasteniy/industry-information/info-gosudarstvennaya-usluga-pogosudarstvennoy-registratsii-pestitsidov-i-agrokhimikatov / (accessed: 26.07.2022).

4. Study of the histostructure of the liver of broiler chickens with chronic imidacloprid intoxication against the background of the use of sorbents / E. G. Gubeeva, K. F. Khalikova, D. V. Aleev [et al.] // Veterinary doctor. 2019. No 1. . 812. DOI 10.33632/1998-698X.2019-1-8-13.

5. Study of sorption properties of shungite and zeolite for the prevention of poisoning of animals with imidacloprid / V. I. Egorov, D. V. Aleev, K. F. Khalikova [et al.] // Actual problems of veterinary medicine : aterials of the international scientific and practical conference dedicated to the 90th anniversary of the birth of Professor V.A. Kirshin, Kazan, 05 - 06 April 2018. Kazan : Federal Center for Toxicological, Radiation and Biological Safety, 2018. . 138-141.

6. Kryukov, V. S. The use of cliptilolite for the prevention of mycotoxicosis / V. S. Kryukov, V. V. Krupinin, A. N. Kotik // Veterinary medicine. 1992. No 912. . 28-29.

7. Justification for the introduction of a combination of inorganic and organic sorbents into the diet of animals with T-2 toxicosis / N. N. Mishina, E. I. Semenov, K. H. Papunidi [et al.] // The Veterinarian. 2019. No 2. . 3037. DOI 10.33632/1998-698X.2019-2-30-37.

8. Perfilova, K. V. Substantiation of the component composition of the complex agent Zeapitox in relation to T-2 toxin in experiments in vitro / K. V. Perfilova, N. N. Mishina, E. I. Semenov // Scientific notes of the Kazan State Academy of Veterinary Medicine named after N.E. Bauman. 2021. Vol. 247. No 3. . 208212. DOI 10.31588/2413-4201-1883-247-3-208-212.

9. The use of highperformance liquid chromatography - time of flight mass spectrometry for the determination of neonicotinoid lethal intoxicants of bees / E. R. Rakhmetova, I. M. Fitsev, A. Z. Mukharlyamova [et al.] // Butlerov messages. 2020. Vol. 63, No 9. . 5967. DOI 10.37952/ROI-jbc-01/20-63-9-59.

10. Sorbent for the prevention of mycotoxicosis of animals / A. I. Samsonov, E. I. Semenov, O. K. Ermolaeva [et al.] // Toxicosis of animals and actual problems of diseases of young animals: International scientific conference, Kazan, October 25-27, 2006. Kazan : Federal Center for Toxicological, Radiation and Biological Safety, 2006. . 172174.

11. Improvement of the methodology for determining the level of imidacloprid in feed by the method of high-performance liquid chromatography / D. D. Khairullin, G. R. Yamalova, K. F. Khalikova [et al.] // Scientific notes of the Kazan State Academy of Veterinary Medicine named after N. E. Bauman. 2017. Vol. 231, No 3. . 154156.

12. Yakupova, L. F. The study of the effectiveness of zeolite and microwave processing of grain affected by mycotoxins on white rats / L. F. Yakupova, E. K. Papunidi, S. Y. Smolentsev // Bulletin of the Mari State University. Series: Agricultural Sciences. Economic sciences. 2022. Vol. 8, No 2(30). P. 166172. DOI 10.30914/2411-9687-2022-8-2-166-172.

13. Matrosova, L. E. Efficiency of enterosorbent for mineralization attenuation in pig mycotoxicosis / L. E. Matrosova, N. N. Mishina, S. A. Tanaseva [et al.] // International Journal of Research and Development in the field of mechanical engineering and production Technology (IJMPERD). 2020. Vol. 10. P. 18511856.

14. Zeolite, hepatoprotector and probiotic in swine aflatoxicosis international / L. Matrosova, S. Tanaseva, E. Tarasova, N. Mishina [et al.] // International Journal of Research and Development in the field of Mechanical Engineering and production Technology (IJMPERD). 2020. Vol. 10. P. 70537060.

 
   
Title:

Monitoring of veterinary safety of areas of extraction (catch) of aquatic biological resources as a mechanism for ensuring food and biological safety of the territory of the Russian Federation (2019-2021)

   
Authors: Ilyas Faritovich Adiatulin1, Vasily Ivanovich Belousov2, 3, Serikbol Beilzhanovich Bazarbaev3 1natsrybbesafety, Moscow, Russia
   
Address:

1Natsrybbesafety, Moscow, Russia

2The All-Russian Scientific Research Institute for Animal Protection, Vladimir, Russia

3Moscow State Academy of Veterinary Medicine and Biotechnology named after K. I. Scriabin, Moscow, Russia

   
Abstract: The article presents the results of monitoring studies of veterinary safety of the catch of aquatic biological resources in the territory of the Russian Federation for the period from 2019 to 2021. A total of 84,216 samples of fish and fish products were examined during the study period, 70% of the samples were taken in marine regions and 30% in inland waters. At the same time, in 119 districts the catches of aquatic biological resources met the requirements of their safety, and in 96 districts they did not meet. The largest number of cases of parasitic infection of aquatic biological resources (637 cases 81.3%) is observed in the marine areas of the Far Eastern Fisheries Basin, of which 318 (91.9%) are in the Sea of Okhotsk. Helminths, histamine, mercury, cadmium, arsenic, organochlorine compounds (HOC) were detected in the samples studied. Recommendations are given on improving the methods of control of fish and fish products produced on the territory of the Russian Federation.
   
Keywords: laboratory tests, fish, catches, pathogens, pollutant
   
References:

1. Veterinary and Sanitary Code of aquatic Animals. World Organization for Animal Health (OIE). URL: http://www.oie.int (date of application:14.04.2023).

 2. Kim, I. N. The main types of falsification of aquatic biological resources / I. N. Kim, A. E. Komin // Technologies of food and processing industry // Agroindustrial complex-healthy food products. - 2021. No. 2. pp.149-153.

3. Malakshinova, N. S. Some issues of protection of aquatic biological resources of the Baikal region. Administrative aspect / N. S. Malakshinova, B. B. Tsybikov, T. P. Batorova // BULLETIN OF VSGUT. - 2015. No. 3. pp. 148-155

 4. Obukhova, O. V. Sanitary and microbiological assessment of the hydroecosystem of the Volga delta under anthropogenic pollution / O. V. Obukhova, L. V. Lartseva, I. A. Lisitskaya // Hygiene and sanitation. - 2009. No. 1. pp. 23-25.

5. Bedritskaya, I. N. The influence of heavy metals on the body of fish grown in the waste waters of power plants: dissertation for the degree of Candidate of Biological Sciences. Troitsk.

6. Technical Regulations of the Eurasian Economic Union "On the safety of fish and fish products" (EAEU TR 040/2016). Official website of the Eurasian Economic Union www.eaeunion.org , 20.03.2017 (date of application: 14.04.2023).

 7. Ponomarenko, A.M. Ecological and fishery aspects of mercury pollution of reservoirs : specialty 03.00.16 "Ecology" : dis. ...cand. biol. sciences / Ponomarenko, Anna Mikhailovna ; Kazan State University named after V.I. Ulyanov-Lenin. Kazan, 2006. 116 p.

 8. Shavyrina, O. B. Some legal aspects of the protection of aquatic biological resources // International Journal of Applied and Fundamental Research. - 2018. No. 10. pp. 126-130.