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¹ 1, 2021
Ñêà÷àòü íîìåð æóðíàëà â ôîðìàòå .pdf (2,30 ÌÁ)Toxicology | |
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Title: | THE EFFECT OF MAGNESIUM AND ZINC ON RATS TREATED WITH CADMIUM |
Authors: | S.N. Potapova |
Address: | Federal Center for Toxicological, Radiation and Biological Safety, 420075 Kazan, Scientific Town-2, å – mail: svetlana150895@yandex.ru, |
Abstract: | The heavily influence of anthropogenic factors
evaluated the level of heavy metals significantly. Cadmium is one of the most
widespread toxins of this group and causes irreparable damage to organism and
agriculture. Some vital elements exhibit protective properties against cadmium,
so the properties of magnesium, zinc and their combinations on changes caused
by cadmium exposure were studied. To this end, Wistar rats was used. Our findings suggested that cadmium exposure reduces the body weight gain of animals, increases
lipid peroxidation, and also has a negative effect on liver, kidney, and
mineral metabolism. The addition of magnesium, zinc and their combinations to
feed partially reduces the effects caused by cadmium, while the use of zinc and
zinc with magnesium in combination was more effective than the use of magnesium
alone. |
Keywords: | cadmium, magnesium, zinc, antagonism, rats |
References: | 1. Wafin, I.F. Combined effect of dioxin and cadmium
chloride on animals and finding therapeutic agents/autoref. diss. on the juice. learned. step. candy vet.
sciences (06.02.03) /Vafin Iskander Foatovich; FSBNU
"FTsTRB-VNIVI." -
Kazan, 2010. – 23ð 2. Konychova, V.A., Kadikov I.R., Korchemkin A.A.,
Papunidi K.H., Aslanov R.M., Matveeva E.L. The results of monitoring of heavy
metals in feed and water in some regions of the Russian Federation // Uchenye zapiski Kazanskoj gosudarstvennoj
akademii veterinarnoj mediciny im. N.E. Baumana - Scientific notes of the
Kazan state Academy of veterinary medicine. N. E. Bauman. –2019. - V.240.
- ¹4 - p. 103. 3. Papunidi,
K.Kh., Biktashev, R.U., Kadikov, I.R., Zakirova, G.Sh. Hematological parameters
and natural resistence of chiken –broilers at diets contamination by heavy
metals and sorbents using // Veterinarnyy vrach - Veterinarian. - 2019,
¹ 4. - p.27. 4. Papunidi, K.Kh, Konyukhov
G.V., Nizamov R.N., Semenov E.I., Kadikov I.R. Kombinirovannyye
porazheniya zhivotnykh i razrabotka sredstv profilaktiki i lecheniya = Combined
damage to animals and the development of means of prevention and treatment / Monograph; ÔÃÁÍÓ.- Kazan, 2019. –p. 248 . 5. European Treaty Series - No. 123 - European Convention
for the Protection of Vertebrate Animals used for Experimental and Other
Scientific Purposes.- Strasbourg, 18.III.1986 6. Hedya Jemaia, Imed Messaoudib, Abdelhamid Chaouchc,
Abdelhamid Kerkeni, Protective effect of zinc supplementation on blood
antioxidant defense system in rats exposed to cadmium // Journal of Trace
Elements in Medicine and Biology.- 2007. - V.21. - p. 269–273. 7. Ibrahim Alhazza, Effect of zinc on cadmium induced
oxidative stress: an in vivo study// World Allergy Organization Journal. -
2015. - V.8 (3).- p. 1. 8. Manal F. Elkhadragy, Rami B. Kassab, Dina Metwally,
Rafa S. Almeer, Rewaida Abdel-Gaber, Ebtesam M. Al-Olayan, Ehab A. Essawy,
Hatem K. Amin and Ahmed E. Abdel Moneim, Protective effects of Fragaria
ananassa methanolic extract in a rat model of cadmium chloride-induced neurotoxicity//
Bioscience Report.- 2018. - V.38. - p.1. 9. Manal F. Elkhadragy, Ahmed E. Abdel Moneim, Protective Effect of Fragaria Ananassa
Methanolic Extract on Cadmium Chloride (CdCl2)-Induced Hepatotoxicity in Rats
// Toxicology Mechanisms and Methods. - 2017. - V.27. - p. 335. 10. Mehmet Kanter, Burhan Aksu, Meryem Akpolat, Yeter
Topcu Tarladacalisir, Cevat Aktas, Hamdi Uysal, Vitamin E Protects against
Oxidative Damage Caused by Cadmium in the Blood of Rats// European Journal of
General Medicine.- 2009. - V.6 (3). - p. 154 11. Ram B. Jain Cadmium and kidney function:
Concentrations, variabilities, and associations across various stages of
glomerular function// Environmental pollution - 2019. - p. 1. 12. Vesna Matovic, Aleksandra Buha, Zorica Bulat,
DanijelaDjukić-Ćosić, Milica Miljkovic, Jasmina Ivaniševic´, Jelena
Kotur-Stevuljevic, Route-dependent effects of cadmium/cadmium and magnesium
acute treatment on parameters of oxidative stress in rat liver // Food and Chemical Toxicology.- 2012. - V.50. - p. 552. 13. Vesna Matović, Zorica PlamenacBulat, Danijela
Djukić-Ćosić, Danilo Soldatović, Antagonism between cadmium and magnesium: a
possible role of magnesium in therapy of cadmium intoxication // Magnesium
Research.- 2010. - V.23 (1). - p. 19. 14. Xiong YW, Zhu HL, Nan Y, Cao XL, Shi XT, Yi SJ, Feng YJ, Zhang C , Gao L, Chen YH , Xu DX, Wang H, Maternal cadmium exposure during late pregnancy
causes fetal growth restriction via inhibiting placental progesterone
synthesis// Ecotoxicology and Environmental Safety.- 2020. - V.187. - p. 1. |
Title: | ACETAMINOPHEN INDUCED HEPATITIS IN LABORATORY ANIMALS |
Authors: | V.O. Dombrovskiy, V.I. Egorov - Candidate of Biological Sciences, I.I. Idiyatov - Candidate of Biological Sciences |
Address: | FSBSI "Federal Center for Toxicological, Radiation and Biological Safety", 420075, Kazan Scientific town-2, e-mail: vnivi@mail.ru. |
Abstract: | Toxic hepatitis is common in human and veterinary
medicine. One of the methods for modeling hepatitis is the administration of
acetaminophen. In human medicine
Acetaminophen overdose is the most frequent cause of ALF (Acute Liver Failure).
Acute toxic hepatitis caused by acetaminophen reversible process, however
chronic acetaminophen hepatitis, judging by the change in the relative size of
the liver and its structure, as well as the level of serum enzymes, is an
irreversible process that leads to deep systemic damage to the organism. |
Keywords: | acetaminophen, acute hepatitis, chronic hepatitis. |
References: | 1. Alyautdin R.N. On the issue of the safety of
acetaminophen / R.N. Alyautdin, V.K. Lepakhin, B.K. Romanov, A.P.
Pereverzev // Safety and risk of pharmacotherapy. 2014. – p. 5. 2. Dombrowskiy, V.O. Overview of the main hepatoprotectors
used in the practice of a veterinarian / V.O. Dombrowskiy // Actual issues of
improving the technology of production and processing of agricultural products:
Mosolov readings: materials of the international scientific-practical conference
/ Mar. state un-t - Yoshkar-Ola, 2020. - Issue. XXII. – p. 462. 3. Ghanem C.I. Acetaminophen from liver to brain: New
insights into drug pharmacological action and toxicity / CI Ghanem, MJ Pérez,
JE Manautou, D.A Mottino. // PharmacolRes. - 2016. – p. 9. 4. Goncharova I. A. Change in liver function during
stimulation and depression of macrophages in rats. Wistar with toxic hepatitis
/ I.A., Goncharova, S.Ya. Zhanaeva, O.A. Levina, O.V. Falameeva, T.A. Korolenko
// Bulletin of the SB RAMS. - 2004.– p. 84. 5. Güvenç M. Nobiletin attenuates acetaminophen-induced
hepatorenal toxicity in rats / M. Güvenç, M. Cellat, İ. Gökçek // J
Biochem Mol Toxicol. 2020. – p. 1. 6. Hu J., Efficacy and safety of acetylcysteine in
"non-acetaminophen" acute liver failure: A meta-analysis of
prospective clinical trials / J. Hu, Q. Zhang, X. Ren, Z. Sun, Q. Quan // Clin
Res Hepatol Gastroenterol. 2015. – p. 594. 7. Khayyat A., N-acetylcysteine amide, a promising
antidote for acetaminophen toxicity / A. Khayyat, S. Tobwala, M. Hart, N. Ercal
// Toxicol Lett. 2016. - p 133. 8. Klimov L.Y. Fulminant liver failure with acetaminophen
/ L.Y. Klimov , A.G. Aksyonov, E.V. Popova, L.V. Pogorelova, R.O. Tsutsaev,
Y.V. Bykov, V.S. Kashnikov, D.V. Bobryshev, V.A. Kuryaninova, M.V. Stoyan, A.D. Pankov
// Literature review and clinical case demonstration // MS. - 2018. - p. 76. 9. Kucheryavenkov M. A. Change in metabolic processes in
hepatitis dogs / M.A. Kucheryavenkov,
V.S. Avdeenko, M.A. Bagmanov, R.N. Safiullov // Uchenye zapiski KGAVM im. N.E.
Bauman. - 2010. – p. 70. 10. Kuzminova E.V. Prospects for expanding the spectrum of
hepatoprotectors in veterinary medicine / E.A. Kuzminova, M.P. Semenenko, E.A.
Starikova, E.V. Tyapkina, A.P. Fersunin // Scientific journal of KubSAU . - 2014.- p. 787. 11. Mohamed A.D. Association of antioxidant nutraceuticals
and acetaminophen (paracetamol): Friend or foe? / A.D. Mohamed, A. I. Abushouk,
R. Reggi, N. S. Yarla, M. Palmery, I. Peluso
// Journal of Food and Drug Analysis, Volume 26, Issue 2, Supplement,
2018. - p. 78. 12. Sheibak V.M., Free amino acids of rat blood plasma
with liver damage with acetaminophen and administration of taurine or a
composition consisting of taurine and zinc sulfate / V. M. Sheybak, M. V.
Goretskaya, V. Y. Smirnov, A. L. Dmitriev // Journal of State Medical University.
2006. – p.110. 13. Simeonova R.
Hepatoprotective and antioxidant effects of saponarin, isolated from
Gypsophila trichotoma Wend. on paracetamol-induced liver damage in rats / R.
Simeonova, V.
Vitcheva, M. Kondeva-Burdina, I. Krasteva, V. Manov, M. Mitcheva // Biomed Res
Int. 757126, 2009. – p. 1. 14. Skuratov A.G., Experimental modeling of toxic liver
damage / A. G. Skuratov, A. N.
Lyzikov, E. V. Voropaev, S. L. Achinovich, Osipov B.B. // Problems of health
and ecology. - 2011. - p. 27. 15. Tropskaya N.S., Change in intestinal microbiota under
the influence of a non-steroidal anti-inflammatory drug acetaminophen / N. S.
Tropskaya, I. G. Vilkova, E. A. Kislyakova, O. S. Kislitsyna, T. V.
Chernenkaya, T.S. Popova // EiKG. 2018. - p. 86. 16. Tunon M. J., “An overview of animal models for
investigating the pathogenesis and therapeutic strategies in acute hepatic
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no. 25, - 2009. - p. 3086. 17. Villar D. Ibuprofen, aspirin and acetaminophen
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// Vet Hum Toxicol. - 2008. p. 156. 18. Vokhmintseva L.V. Features of the functional activity
of neutrophils in rats with periodontal inflammation in the presence of toxic
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Mayanskaya, S. S. Rymar, P. A. Zhelezny, A. P. Nadeev, V.V. Vanyunina //
Bulletin of Siberian medicine. - 2007. –
p. 11. |
Title: | MINIMIZATION OF THE MATRIX EFFECT WHEN INDICATING T-2 TOXIN BY IN-ELISA IN PLANT SAMPLES |
Authors: | I.N. Shtyrov, A.F. Khasiyatullin, A.R. Valiev, Candidate of Biological Sciences, E. Yu. Tarasova, Candidate of Biological Sciences, N.N. Mishina, Candidate of Biological Sciences, Leading Researcher, E. I. Semenov, Doctor of Veterinary Sciences, |
Address: | Federal Center for Toxicological, Radiation and Biological Safety, 420075 Kazan, Scientific Town-2, |
Abstract: | This article explores the possibility of minimizing
the matrix effect when indicated by indirect enzyme-linked immunosorbent assay
(indirect ELISA) in complex plant samples (wheat, corn and silage) from
artificially and naturally contaminated samples. The study of the influence of
the percentage of methanol (10 -50%) in the extracting mixture on the degree of
T-2 toxin extraction showed that all mixtures provide the extraction of
mycotoxin from truly positive samples, both when studying the matrix effect and
without it. The smallest deviation in the study of mycotoxin content in the
control sample containing T-2 toxin at the rate of 100 μg / kg (control sample
100 – CSA100) without matrix effect was observed using 40 and 50% methanol,
which was ± 0.98%. However, when using 50% methanol in the extraction of
mycotoxin from plant samples, the maximum matrix effect was observed,
especially from corn and silage, which is probably due to the maximum
extraction and coloring pigments. The value of the matrix effect was in direct
proportion to the amount of methanol in the extracting mixture — the less
methanol, the less the matrix effect. With almost equal deviations in the
concentration of CSA100 from plant samples using 40 and 50% methanol, the
deviation in CSA100 was 0.98 and -1.32, respectively. It was found that when
using a 40% aqueous solution of methanol, a minimal matrix effect is achieved
both in simple plant residues (wheat) and complex ones (corn, silage), as well
as the maximum extraction of T-2 toxin. |
Keywords: | T-2 toxin, ELISA, matrix effect. |
References: | 1. Goryacheva, I.Yu. Immunochemical methods for the determination of
mycotoxins. / I.Yu. Goryacheva, T.Yu. Rusanova, N.A. Burmistrova, S. De. Saeger
// Journal of Analytical Chemistry. - 64. - No. 8. –2009. - C. 788. 2. Adhikari, M. T-2 mycotoxin: toxicological effects and decontamination
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- 8. - 2017. - p. 33933. 3. Agrawal, M. Lakshmana Rao Involvement of mitogen-activated protein
kinase pathway in T-2 toxin-induced cell cycle alteration and apoptosis in
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–51. - 2015 .- p. 1379. 4. Chen, D. Development of a liquid chromatography-tandem mass
spectrometry with ultrasound-assisted extraction method for the simultaneous
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Zhang // J. Agric. Food Chem., - 62. - 2014. - p. 1492. 9. Li, Y. T-2 toxin, a trichothecene mycotoxin: review of toxicity,
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Radiobiology | |
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Title: | CHOOSING THE OPTIMAL MODEL OF TWO-FACTOR PATHOLOGY CAUSED BY THERMAL LESION AGAINST THE BACKGROUND OF EXTERNAL GAMMA - RADIATION |
Authors: | 1 T.R. Gaynutdinov– Candidate of Biological Sciences, 1 K.N. Vagin - Candidate of Biological Sciences, 1A.M. Idrisov– Candidate of Veterinarian. Sciences, Associate Professor, 2V.G. Semenov - Doctor of Biological Sciences, Professor, 1V.A. Guryanova - Candidate of Biological Sciences. |
Address: | 1FSBSI
"Federal Center for Toxicological, Radiation and Biological Safety", 420075, Kazan Scientific town-2, e-mail: vnivi@mail.ru. 2Federal
State Budgetary Educational Institution of Higher Professional Education «Chuvash State Agricultural
University», 428003
Cheboksary City , 29. K. Marks Street, e-mail:
office@chuvcu.ru. |
Abstract: | Experimental
modeling of acute radiation and burn disease separately and their combination
was carried out. It has been established that external total gamma-radiation of
white rats at a dose of 7.5 Gr causes severe radiation sickness with
characteristic clinical features and high lethality of the irradiated
population. It is noted that the degree of thermal injury (burn) is affected by
the time of holding on the surface of the
body heated to 190 degrees Celsius of a metal plate: its application for 5
seconds causes burn III A degree, 8 - second exposure - III B degree, as
evidenced by the timing of formation, rejection of the burn strup and full
healing of thermal damage. The aggravating effect of ionizing radiation on the
course and the outcome of the combined radiation-thermal pathology is shown. |
Keywords: | ionizing radiation, burn IIIA and IIIB degree, combined radiation-thermal lesion. |
References: | 1. Avetisov, G.M. Acute Radiation Syndrome. Clinical manifestations,
prevention and treatment /G.M.Avetisov, V.G.Vladimirov, S.F.Goncharov, etc. -
M.: VMC "Protection", 2003. - 244 s. 2. Gaynutdinov, T.R. Evaluation of the effectiveness of drugs for the
treatment of combined radiation-thermal lesions / T.R. Gaynutdinov, G.V.
Konyukhov, A.M. Idrisov, V.P. Shacharov, N.B. Tarasova, V.A. Guryanov //
Veterinarian - 2018. - No 5. S. 49-52. 3. Gaynutdinov, T.R. Pathogenez
combined radiation-thermal lesions at various degrees of burns /
T.R.Gaynutdinov, V.P.Shashkinov, A.M.Idrisov, N.M.Vasilevskiy, V.A.Guryanova,
N.B.Tarasova // Scientific and practical journal "Veterinary. It's a
zootechnia. Biology." Moscow, 2018. - No 10. S. 29-34. 4. Gaynutdinov, T.R. Receiving
and studying the effectiveness of drugs for the treatment of combined
radiation-thermal lesions / T.R.Gaynutdinov //Mater. It's all over.
in-practice. young scientists, graduate students and students "Ecology and
security in the technosphere: modern problems and ways to solve them."
Tomsk, November 23-25, 2017. S. 582-586. 5. Gaynutdinov, T.R. Method of
obtaining a drug for the treatment of combined radiation-thermal damage of the
body / T.R.Gaynutdinov, K.N.Vagin, R.N.Nizamov //Scientists of the notes of the
educational institution of the Vitebsk Order of Honor of the State Academy of
Veterinary Medicine. 2018. T. 54. No 4. S. 32-37. 6. Zargarova, N.I. Experimental study of the mechanisms of the
phenomenon of mutual weighting in the combined radiation lesions and the
effectiveness of the means of its modification /N.I.S. Sargarov, V.I.Legez,
A.N.Grebenyuk, A.J.Kondakov //VII Congress on Radiation Research: thesis of
reports. - Moscow, October 21-24, 2014. 142 s. 7. Pat. No 2686843 Russian Federation, C1, IPC A61K 36/15, A61R17/02.
The method of treatment of combined radiation-thermal lesions and the means for
its implementation / T.R.Gaynutdinov, R.N.Nizamov, A.I.Nikitin, G.V.Konyukhov,
R.F.Shavaliev, V.P.Shashkinov, A.M.Idrisov, M.V. Kharitonov; the federal state
budgetary scientific institution ,Federal Center for Toxicology, Radiation and
Biological Security (FGBNU "FTCRB-VNIVI"). - No 2018104917,
08.02.2018; Swollen. May 6, 2019, Buhl. No 13. 8. Shashkarov, V.P. Experimental assessment of pathogenesis, current and
outcome of acute radiation and combined radiation-thermal lesions in
experiments on laboratory animals /V.P.Shashkarov, T.R.Gaynutdinov, A.M.Idrisov
//Mat. It's all over. in-practice. young scientists, graduate students and
students "Ecology and security in the technosphere: modern problems and
ways to solve them." Tomsk, November 22-24, 2018. S. 280-284. |
Title: | COMBINED EFFECTS OF GAMMA-RADIATION AND EIMERIA ON THE ORGANISM OF RABBITS |
Authors: | Idrisov A.M. – Ñandidate of Veterinarian. Sciences, Associate Professor, Gaynutdinov T.R. – Candidate of Biological Sciences, Vagin K.N. – Candidate of Biological Sciences, Vasilevsky N.M. – Doctor of Veterinarian Sciences, Professor, Kalimullin F.Kh. - Candidate of Biological Sciences, Mayorova E.N. - Candidate of Biological Sciences, Rakhmatullina G.I. - Candidate of Biological Sciences. |
Address: | FSBSI "Federal Center for Toxicological, radiation and biological safety " 420075, Kazan, 2 Nauchny gorodok st; e-mail: vnivi@mail.ru. |
Abstract: | Based on the conceptual
position of radiation parasitology about a certain commonality of the
mechanisms of the pathogenic effect of ionizing radiation and biological agents
on living organisms, we have determined the conditions for modeling parasitic
damage to the body by agents of biological etiology. Irradiation of rabbits at
a dose of 8.0 Gy and infection with eimeria at a dose of 85 thousand eimeria
oocysts cause severe radiation sickness, aggravating the course of the
coccidial process and promoting its generalization, which accelerates the death
of animals. The combined radiation and biological damage proceeds quickly and
the animals die 6-9 days after the onset of the disease. |
Keywords: | rabbits, combined lesions, gamma irradiation, acute radiation sickness, coccidiosis, oocysts, Eimeria. |
References: | Anikanov, V.S. Coccidia of rabbits, minks and foxes of
cell breeding (taxonomy, biology, ecology). Petrozavodsk: Karelian Scientific
Center of the Russian Academy of Sciences, - 1994, - p. 35. 2. Budarkov, V.A. Radiobiology. Radiation safety of
farm animals // V.A. Budarkov, A.S. Zenkin, A.V. Vasiliev et
al. / Ed. prof. V.A. Budarkov and prof. Zenkina A.S. Tutorial. M .: Kolos, - 2018.
- p. 440. 3. Gaynutdinov, T.R. Determination of the resistance of
colibacillosis causative agents to the effects of ionizing radiation / T.R.
Gaynutdinov, V.P. Shashkarov, A.M. Idrisov, Ya.M. Kurbangaleev,
G.N. Spiridonov, V.A. Guryanova // International scientific-practical. conf.
dedicated to the 50th anniversary of the foundation of the Federal State
Budgetary Scientific Institution All-Russian Research Institute of Radiology
and Agroecology "Nuclear Physics Research and Technologies in
Agriculture". - FGBNU VNIIRAE. - Obninsk, September 16-18, 2020. - p. 46. 4. Gaynutdinov, T.R. Pathogenesis of combined
radiation-thermal injuries at various degrees of burns / T.R. Gaynutdinov, V.P.
Shashkarov, A.M. Idrisov, N.M. Vasilevsky, V.A. Guryanova, N.B. Tarasova //
Scientific and practical journal "Veterinary Medicine. Animal science.
Biology". - Moscow, 2018. - No. 10. - p. 29. 5. Gaynutdinov, T.R. The course of acute radiation
sickness against the background of natural infection of animals with agents of
biological nature / T.R. Gaynutdinov, A.M. Idrisov, K.N. Vagin, N.M. Vasilevsky, G.Sh.
Zakirova, Ya.M. Kurbangaleev, V.G. Semenov // "Veterinarian". -
Kazan, - 2020. - No. 6. - p. 15. 6. Grebenyuk, A.N. Fundamentals of radiobiology and
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Legeza, E. N. Stepanova: Textbook. - SPb .: LLC "FOLIANT Publishing
House", 2012. - p. 232. 7. Latypov, D.G. Helminthiasis of animals and humans
(anthropozoonoses) / D.G. Latypov, I.N. Zalyalov, L.A. Gaisina, T.S. Gosmanova
- Kazan, 2011. - p. 462. 8. Kireenko, K.M. Morphological changes in field mouse
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48 (1).- p. 289. |
VETERINARY PHARMACOLOGY WITH TOXICOLOGY | |
---|---|
Title: | EFFECT OF A NEW PREPARATION BASED ON ORGANIC ACIDS ON DIGESTION AND SOME INDICATORS OF METABOLISM IN BROILER CHICKENS |
Authors: | Kolomiets S. N. - doctor of biological Sciences, Vasilyeva K. V. |
Address: | FSBEI «Moscow State Academy of Veterinary Medicine and Biotechnology –MVA named after K.I. Skryabin», Moscow, Russia, E-mail: colomiez@mail.ru |
Abstract: | The article discusses the effect of introducing a
complex feed additive-acidifier in various doses to the diets of broiler
chickens on digestion and metabolism. The positive effect of the drug on the
indicators of digestibility and biochemical parameters of blood was
established. |
Keywords: | chickens, organic acids, digestibility, metabolism. |
References: | 1. Metodika provedeniya nauchnyh i proizvodstvennyh issledovanij po
kormleniyu sel'skohozyajstvennoj pticy / pod obshch. red. V.I. Fisinina. –
Sergiev Posad, 2004 -33s. 2. Metodicheskie rekomendacii po gematologicheskim i biohimicheskim
issledovaniyam u kur sovremennyh krossov / I.V. Nasonov., N.V. Bujko, R.P.
Lizun, V.E. Volohina, N.V. Zaharik
[i dr.]. –Minsk, 2014. – 32ð. 3. Metody nauchnyh issledovanij v zhivotnovodstve / N.V. Lyashenko, M.S.
Galicheva. - Majkop. – ð.52. 4. Obshchie i special'nye metody issledovaniya krovi ptic promyshlennyh
krossov/ N.V. Sadovnikov. –
Ekateriburg; SPb., 2009. – 85ð. 5. Okolelova, T.M. Al'ternativa kormovym antibiotikam / T.M. Okolelova,
A.V. Korolev // Pticevodstvo. -2016. -¹ 8. - ð.24. 6. Pol Dens. Primenenie organicheskih kislot v pticevodstve / ZHurnal
Farm Animals. – 2013. – ð.78. 7. Sigall, R. Sinergizm efirnyh masel i organicheskih kislot kak
al'ternativa antibiotikam / R. Sigall,
A. Plohova // Kombikorma. – 2011. – ¹ 3. – ð. 91 8. Teobal'd P. Opyt ispol'zovaniya organicheskih kislot v kormlenii
svinej v Evrope / P.
Teobal'd, K. Lyukshtadt // Notingem. – 2011.- ¹ 1- Ñ 25. 9. Choct.M. Alternatives to In- feed antibiotics in monogastric animal
industry, ASA Technucal Bulletin. -vol. AN30. – 2001. 10. Margaret A. Wissman, D.V.M., D.A.B.V.P. Avian Plasma Proteins, 2006.
www.exoticpetvet.net. 11. Nilipour, A.H., Yegan, M., and Butcher, G.D. 2001. How nutrition
affect immune response in poultry, word Poultry- Elsevier, 17 (6), - ð.42. |
VETERINARY VIROLOGY, EPIZOOTOLOGY AND ANIMAL THERAPY | |
---|---|
Title: | ANTIBACTERIAL PROPERTIES OF THE HIGHER MUSHROOM COPRINUS COMATUS |
Authors: | N.N.Shulga, Doctor of Veterinary Sciences, I.S.Shulga, candidate of biological sciences S.S. Dikunina, E. P. Kotelnikova, |
Address: | FSBNU Far Eastern Zonal Scientific Research Veterinary Institute, 675005, Amur region, Blagoveshchensk, st. Severnaya, 112, dalznivilabvirus@mail.ru |
Abstract: | Conducted research on the search and development of
antiviral drugs based on compounds of natural origin, with a milder therapeutic
effect and low toxicity compared to synthetic drugs. If the twentieth century
is rightfully considered the “era of antibiotics” when many dozens of
antibiotics that were active against a number of infectious diseases were
isolated from micromycetes, then in the 21st century, research shifted towards
macromycetes from various classes. In experiments, a 10% tincture of Coprinus
comatus and 5 field cultures of microorganisms of the intestinal group isolated
from diarrhea-infected calves (Citrobacter diversus, Enterobacter cloacae,
Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa) were used. Diurnal
cultures grown on nutrient agar were washed off with sterile saline. The
bacterial wash was adjusted to a density corresponding to 0.5 according to the
McFarland turbidity standard. A bacterial suspension was sown with a lawn on
the surface of a Petri dish with meat peptone agar (MPA) in a volume of 1-2 ml,
evenly distributed over the surface of the cup by shaking, the excess culture
was removed with a pipette. After that, the Petri dishes were dried at room
temperature for 15 minutes, then paper discs with a diameter of 6 mm were
preliminarily moistened with tincture of the mushroom. The incubation of crops
was carried out at t 370 C for 24 hours. As a result of experiments, it was
found that the tincture of Coprinus comatus delays the growth of field virulent
strains of the pathogens Citrobacter diversus, Enterobacter cloacae,
Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa on the artificial
nutrient medium MPA. The use of tincture of Coprinus comatus as a medicinal
product is indicated for intestinal diseases, in the pathogenesis of which
pathogenic microorganisms participate: Citrobacter diversus, Enterobacter
cloacae, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa. |
Keywords: | coprinus comatus, water-ethanol tincture of the fungus, culture test, growth retardation, antibacterial activity. |
References: | 1. Ogarkov
B.N., Ogarkova G.R., Samusenok L.V. Technological cultures of medicinal
mushrooms and their biological activity // Advances in medical mycology. - 2015
.- T. 14. - ð. 446. 2.
Mazurkova N.A., Filippova E.I., Makarevich E.V., Lobanova I.E., Vysochina G.I.
Higher plants as a basis for the development of anti-influenza drugs. //
Questions of biological, medical and pharmaceutical chemistry. - 2014. - No. 4.
- p. 55 3.
Felippova E.I., Mazurkov O.Yu., Gorbunova I.A., Kostina N.E., Mazurkova N.A.
Antiviral properties of water and ethanol extracts of shaggy dung beetle
(coprinus comatus) in vitro and in vivo against influenza virus // Antibiotics
and chemotherapy. - 2018. - T. 63. - No. 11. - ð. 8. 4.
Sarkina I.S., Mironova L.P. Annotated list of basidial and marsupial
macromycetes of the Karadag nature reserve. // Scientific notes of the natural
reserve "Cape Martyan". - 2015. - No. 6 - ð. 297. 5.
Teplyakova TV Pharma mushroom: mushrooms against viruses and tumors. // Science
first hand. - 2017. - No. 5 (76). - ð.106. 6.
Lomberg M.L., Bukhalo A.S., Polyukh N.P. Growth of cultures of coprinus comatus
(o.f. mull.) Pers. on liquid nutrient media. // Advances in medical mycology. -
2014. - T.12. - ð. 239. 7.
Efimenko T.A., Vasilyeva B.F., Glukhova A.A., Malanicheva I.A., Sumarukova
I.G., Efremenkova O.V. Antimicrobial activity of endobionts of fruit bodies of
basidiomycetes. // Advances in medical mycology. - 2018. - T.18. - ð. 235. 8.Efimenko
T.A., Malanicheva I.A., Vasilyeva B.F., Glukhova A.A., Sumarukova I.G., Boykova
Yu.V., Malkina N.D., Terekhova L.P., Efremenkova O.V. Antibiotic activity of
bacteria - endobionts of fruit bodies of basidiomycetes. // Microbiology. -
2016. - T. 85. - No. 6. - ð. 740. 9.Kostina
N.E., Ibragimova Zh.B., Protsenko M.A., Makarevich E.V., Skarnovich M.A.,
Filippova E.I., Gorbunova I.A., Vlasenko V.A., Troshkova G.P., Mazurkova N.A.,
Shishkina L.N. Isolation, characterization and antiviral properties of
biologically active substances from higher fungi of Western Siberia. // Modern
problems of science and education. - 2013. - No. 3. - p. 336. 10.
Bergey's guide to bacteria. At 2mm. / Hold J., Krieg N., Snith P., Stelmi J.,
Williams S.M. // M .: Mir. 1997. 11.
Sidorov M.A., Skorodumov D.I., Fedotov V.B. Keys to zoopathogenic
microorganisms // Handbook. Ed. Sidorov M.A. M .: Kolos. 1995. |
Title: | BRUCELLOSIS: ITS DISTRIBUTION AND PREVENTION. |
Authors: | R.Yu. Nasibullin, L.A. Tukhvatullina, Ya.A. Bogova, G.M. Safina - candidate of veterinary sciences, leading scientist, M.A. Kosarev- candidate of biological sciences, head of laboratory. |
Address: | FSBSI «Federal Center for Toxicological, Radiation and Biological Safety, Kazan». 420075, Kazan, Nauchny gorodok-2, e-mail: vnivi @ mail.ru |
Abstract: | The present work describes the features of the
distribution of brucellosis, the potential risk factors and economic impact in
the case of brucellosis.The epidemiological situation for brucellosis has not
tended to improve over the past years. Epizootiological situation in the
Russian Federation remains reasonably tense.The epidemiological situation in
the Russian Federation for brucellosis has not tended to improve over the past
years.The epizootic ill-being of animal stock for brucellosis and violations of
sanitary and hygiene standards and rules of conduction of animal husbandry are
main reasons of widespread infection and economic losses in the livestock
agriculture. The problem of the incidence of brucellosis becomes especially
actuality to conduct transformations in agricultural area, whichaim at
increasing the number of farm animals (livestock, small stock).Our results show
examples of the use of specific preventive medicines againstbrucellosis for
salvation actual tasks of preventing the spread of brucellosis among farm
animals. |
Keywords: | brucellosis, brucella, vaccine, morbidity, immunoprophylaxis, analysis, cattle, small ruminants, lymph nodes. |
References: | . Gorchakova, N.G. Features of the parasitic system of brucellosis /
N.G. Gorchakova/ Scientific research
publications. - 2017. - ¹ 4.- p.14. 2. Information resource site of the Federal Service for Veterinary and
Phytosanitary Surveillance / Review of the epidemiological and epizootic
situation of brucellosis in the world in 2018 and forecast for 2019 in the
Russian Federation/ http://www.rsnso.ru/documents
/publications/?n=2367&tag=%D0%B1%D1%80%D1%83%D1%86%D0%B5%D0%BB%D0%BB%D0%B5%D0%B7, Publication of 02.20.2019 3. Konopatkin, A.A. Epizootology and infectious diseases of farm animals
/ A.A. Konopatkin,
I.À. Bakulov, Ya.V. Nyikin et al // Textbooks and teaching aids for
higher agricultural educational institutions.- Ì.: Kolos.-1984. – 544 p. 4. Litusov, N.V. The causative agents of brucellosis. / N.V. Litusov //
Illustrated textbook. - Yekaterinburg: Publishing House of USMA, 2012. - 38 p. 5. Skliarov, O.D. Brucellosis / O.D Skliarov / Presentation // FSI
Russian State Budgetary Center for the Quality and Standardization of Medicines
for Animals and Feed (FSBI VGNKI) - 25 slides. 6. Tsirelson, L.E. The state of specific immunoprophylaxis of
brucellosis in the Russian Federation /
L.E. Tsirelson, Ì.Ì. Zheludkov,
O.D. Skliarov, V.N. Borovoi // Epidemiology and vaccinal prevention. -
2011. - ¹ 1 (56). - p.59. |
Title: | USE OF THE ASSOCIATED VACCINE AND HYPERIMMUNE SERUM IN THE MIXED FORM OF INFECTIOUS DIARRHEA OF NEWBORN PIGLETS |
Authors: | A.F. Makhmutov - Candidate of Biological Sciences, A.G. Spiridopnov - Candidate of Biological Sciences, G.N.Spiridonov - Dr. of Biological Sciences |
Address: | Federal Center for Toxicological, Radiation and Biological Safety, 420075 Kazan, Scientific Town-2, e-mail: vnivi@mail.ru |
Abstract: | The limiting
factor for full intensification of pig production are various diseases that it
is necessary to promptly prevent and treat. I t is established that an
important etiologic role in the occurrence of gastrointestinal diseases piglets
play Rota-, coronavirus and Escherichia coli. The aim of this work was the
development of technology of manufacture of associated vaccine against Rota-,
coronavirus gastroenteritis and esherihioznae diarrhea of newborn piglets and
getting polyspecificity hyperimmune serum against Rota-, coronavirus
gastroenteritis and diarrhea esherihioznae pigs on pig producers. With this
purpose we studied the safety, antigenic and immunogenic activity of the
vaccine and hyperimmune serum in laboratory animals, pregnant sows and
piglets. Preventive vaccine and
prophylactic properties polyspecificity serum confirmed in farms, stationary-unfavorable
for infectious diarrhea of piglets.Based on the synergistic Association of
rotavirus, virus of transmissible gastroenteritis in pigs and E. coli
synthesizing adhesive antigens Ê88, Ê99 987Ð developed by associated vaccine
for specific prevention of diarrhoea of newborn piglets of mixed etiology. Polyspecificity the use of hyperimmune serum
in a production environment allows us to achieve high economic efficiency in
the treatment and prevention of mixed Rota-, coronavirus and esherihioznae
infections of piglets. The positive results of the production testing of
associated vaccine and hyperimmune serum polyspecificity allow to recommend
them for implementation in veterinary practice with therapeutic and preventive
purposes against transmissible gastroenteritis, rotavirus disease and
esherihioznae diarrhea of newborn piglets. |
Keywords: | hyperimmune serum, Esherichia ñoli, rotavirus, coronavirus, diarrhea in piglets, gastroenteritis, vaccine, immunogenicity, treatment, prophylaxis. |
References: | . GOST 28085-2013 Âiological medicinal ðroducts for
veterinary use. Method of bacteriological control of sterility. - M.-2013. - 26
p. 2. GOST 31926-2013 Medicinal ðroducts for veterinary
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the welfare of the economy / E. Eliseeva // Pig Breeding, - 2008, - No. 4, - p.
24. 4. Kondrakhin I.P.
Methods of veterinary clinical laboratory diagnostics: Reference book / I.P. Kondrakhin. - M .: KolosS, 2004 .- 520
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gastrointestinal diseases of newborn piglets in the regions of the Middle Volga
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their immunoprophylaxis in modern conditions / A.M. Rakhmanov, N. A. Yarmenko
// Actual problems of diseases of young animals in modern conditions: Mater.
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/ / V. S. Rusaliev, V. M. Gnevashev, O. V. Pruntova. - Veterinary
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/ / pig Breeding. - 2009. - ¹1. - p. 25. |
Title: | EPIZOOTIC CHARACTERISTICS OF STATIONARY ANTHRAX UNFAVORABLE POINTS IN THE REPUBLIC OF TATARSTAN |
Authors: | Rodionov A.P., Artemieva E.A. – candidate of veterinary sciences, Melnikova L.A. - candidate of veterinary sciences, Kosarev M.A. - candidate of biological sciences |
Address: | Federal Center for Toxicological, Radiation and Biological Safety, 420075 Kazan, Scientific Town-2,
å – mail: svetlana150895@yandex.ru, |
Abstract: | Anthrax is a particularly dangerous infectious disease
common to humans and animals, and continues to pose a serious threat to animal
husbandry and health care in most countries of the world. The disadvantage of this infection is mainly
based on the ability of the pathogen to form spores that can persist in the
environment for decades. Numerous
anthrax epizootics that have occurred in the past have led to the formation of
persistent soil foci of the pathogen, which are currently the main risk factor
contributing to the emergence of new outbreaks of the disease. In this regard, the regular characterization
of settlements that are permanently dysfunctional in terms of anthrax is an
urgent task that makes it possible to assess the degree of danger of a
particular focus of infection. The
purpose of this work was to carry out the epizootological characteristics of
the stations, which are stationary for anthrax, located on the territory of the
Republic of Tatarstan. The material for
the study was the data of the Main Directorate of Veterinary Medicine of the
Cabinet of Ministers of the Republic of Tatarstan, as well as the cadastre of
settlements of the republic that are permanently unfavorable for anthrax. The classification of disadvantaged items was
carried out according to the method proposed by B.L. Cherkassky.
As a result of the study, it was revealed that, according to the
classification used, out of 1208 stationary dysfunctional items, 1204 refer to
old non-manifest ones that showed their activity more than 10 years ago. One unfavorable point, the village of Lyuga,
Kukmor district, can be classified as an old relapsing one, the last sporadic
outbreak of infection in which was registered in 2014. Three unfavorable points should be classified
as new. Epizootic activity in these
points was noted from 17 to 20 years ago, which indicates the stabilization of
the situation with the spread of soil foci of infection. |
Keywords: | anthrax, stationary anthrax unfavorable points, epizootic characteristics, Republic of Tatarstan, soil foci. |
References: | 1. Artemieva, E.A. Test of the
"Kit for determining the titer of antibodies in the serum of cattle
vaccinated against anthrax in the RNGA" for compliance with technical
conditions / Å.À. Artemieva, L.A. Melnikova, A.P. Rodionov // Veterinarian. - 2020. - No. 6. - p. 5. 2. Buravtseva, N. P.
Epizootological and epidemiological characteristics of stationary
anthrax-unfavorable points in the Stavropol Territory and the North Caucasus
Federal District / N.P. Buravtseva,
V.M. Mezentsev, A.G. Ryazanova et al. // Problems of especially
dangerous infections. - 2016. - No.
2. - p. 36. 3. Ivanova, S.V. Evaluation of
the preventive properties of blood serum of cattle sampled at different times
after vaccination against anthrax / S.V.
Ivanova, L.A. Melnikova, A.P.
Rodionov et al. // Veterinarian.
- 2019. - No. 6. - p. 32. 4. Makayev, Kh.N. Assessment of
the risk of possible outbreaks of anthrax in the Republic of Tatarstan /
Kh.N. Makaev, S.V. Ivanova, L.A.
Melnikova et al. // Kazan Medical Journal. - 2020. - No. 6. - p. 883. 5. Rodionov, A.P. Characteristics
of the epizootic situation for anthrax in the Republic of Tatarstan / A.P. Rodionov, S.V. Ivanova, L.A.
Melnikova et al. // Veterinary Medicine.
- 2020. - No. 3. - p. 8. 6. Selyaninov, Yu.O. Anthrax in
Yamal. Causes and problems of diagnosis
/ Yu. O. Selyaninov, I. Yu. Egorova, D.V.
Sausages // Veterinary Medicine.
- 2016. - No. 10. - p. 3. 7. Ivanova, S.V. Analysis of the
epizootic situation and improvement of the scheme for the specific prevention
of anthrax / S.V. Ivanova, L.A. Melnikova, A.P. Rodionov et al. // International Journal of Research in
Pharmaceutical Sciences. - 2020. - No. 1. - p. 949. |
Title: | EFFECT OF PROBIOTIC FEED ADDITIVE APPLICATION ON GROWTH, DEVELOPMENT AND PRODUCTIVE QUALITIES OF CROSS-ROSS BROILER CHICKENS 308 |
Authors: | Kolomiets S. N. - doctor of biological Sciences, associate Professor, Vasilyeva K. V. |
Address: | FSBEI «Moscow
State Academy of Veterinary Medicine and Biotechnology –MVA named after K.I.
Skryabin», Moscow, Russia, E-mail: colomiez@mail.ru |
Abstract: | The use of organic acids and their salts as acidifiers
in diets has a positive effect on the growth rate of farm animals and poultry.
The growth rate and other zootechnical indicators depend on the correct
selection of organic acid necessary to achieve a certain goal, the dosage of
the corresponding acid, as well as the selection of different types of
introduced acids to achieve a certain synergy effect and the overall buffer
capacity of the feed [8]. Experiments are being conducted in the direction of
selecting various combinations with additional substances, such as essential
oils, prebiotics, probiotics, etc. their optimal combination to create a
universal drug that acts at different levels of acidity. One of the fundamental
factors that predispose to the widespread use of such drugs in poultry farming
is the lack of restrictions on the use of the resulting final products. |
Keywords: | organic acids, probiotic, anatomical cutting, muscle tissue, internal organs. |
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