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¹ 6, 2013

  Toxicology
   
Title:

EVALUATION OF VITA-FORCE NATURAL FODDER ADDITIVE FOR TOXICITY AND SAFETY

   
Authors: Sychev K.V.; Nizamov R.N.; Konyukhov G.V.
   
Address: Federal Center for Toxicological, Radiation and Biological Safety, Kazan.
   
Abstract: The worsening of the ecological situation requires developing means having multifunctional medical and preventive properties. Regarding the Vita-Force drug complexity it is necessary to study its properties on toxicity and safety for animals.
The obtained data evidence that «Vita-Force» fodder additive has low toxicity and complies with the IV class of hazard according to the All-Union state standard 12.1.00.7-76. The results of body mass indexes and hematological studies showed the rats fed with  the «Vita-Force» rats during a month demonstrated total mass increase by 13.2%, and performance  - by 16.9% including  stimulating effect on hematopoiesis: the number of both red cells increased by 1.04 timesand leukoblast cells increased by 1,05 times comparing to the control groups.
   
Keywords: phytogenous drugs, zoogenous drugs, Vita-Force
   
   
   
Title:

USING THERAPEUTICALS FOR SWINE CARDIOMYOCYTES ULTRASTRUCTURE AFFECTED BY DIOXINE, T-2 TOXIN

   
Authors: Saitov V.R.
   
Address: Federal Center for Toxicological, Radiation and Biological Safety, Kazan.
   
Abstract: Currently, more than 40 thousand synthetic and natural compounds are known to be dangerous for animal and human. Most of these compounds may have real threat not only individually but in certain associations too.
The study of associated exposure of toxicants of different groups on ultrathin level is reasonable. On one hand it will allow research the suggested effect of such exposure on the other, to use findings and developed data in case such toxication really occurs.
The aim of our research was the study of the way dioxin and T-2 toxin affect swine cardiomyocytes ultrastructure individually, in associated manner and along with zeolite and dimephosphone. The experiments involved 8 groups of Yorkshire piglets. In chronic oral challenge we used dioxin in dosages of LD50 1/400, 1/600, 1/800 and T-2 toxin in 2-fold MAC (maximum allowable concentration) level during 45 days. One group of animals was additionally introduced 15-% solution of dimephosphone (immunomodulator and stabilizer of cellular membrane) and zeolite absorbent in 2% per diet ratio.
The investigation results showed that the most serious structural and functional alterations took place at associated exposure of dioxin and t-2 toxin (dioxin LD50 1/400 and T-2 toxin in 2-fold MAC): cytoplasm clarification with loosely placed fibrilla, formation of electronically transparent cavity around the nucleus (ribosome-free cytoplasm), mitochondria mostly have clarified matrix, absence of calcium deposits.
Zeolite and dimephosphone in the proposed dosages had an expressed therapeutic effect as treatment means on cellular level.
   
Keywords: ultrastructure, cardiomyocytes, mitochondria, swine, dioxin, T-2 toxin
   
   
   
Title:

USING THERAPEUTICALS FOR SWINE HEPATOCYTIC ULTRASTRUCTURE AFFECTED BY DIOXINE, T-2 TOXIN

   
Authors: Saitov V.R.; Ivanov A.V.; Papunidi K.Kh.; Salnikova M.M.
   
Address: Federal State-Funded Organization «FederalCenter for Toxicological, Radiation, and Biological Safety» (FCTRBS-ARRVI).
   
Abstract: Basing on processes and substances alien to biosphere is a drawback ofthemostcurrenttechnologies. Some of the toxicants are known as dangerous mutagens and oncogens. It is also known that their affect often strengthens at associated exposure on biological entities. In this regard investigation of the way associated introduction of dioxin and T-2 toxin influences on mammal organism on ultrathin level is of high scientific interest.
The aim of our investigations was the study of associated effect of dioxin and T-2toxin as contaminants of different groups on swine hepatocytic ultrastructure separately, in associated way, and along with using zeolite and dimephosphone.
For this purpose the piglets of Yorkshire breed were divided into 8 groups. For chronic oral challenge dioxin was used in dosage of LD50 1/400, 1/600, 1/800 and T-2 toxin was 2-fold MAC (maximum allowable concentration) level during 45 days. One group of animals was additionally introduced 15-% solution of dimephosphone (immunomodulator and stabilizer of cellular membrane) and zeolite absorbent in 2% per diet ratio.
The investigation results showed that associated exposure of ecotoxicants cause considerable alteration of hepatocytes ultrastructure.
   
Keywords: ultrastructure, hepatocytes, mitochondria, swine, dioxin, T-2 toxin
   
   
   
Title:

ADSORPTIVE PROPERTIES OF BENTONITE CONCERNING HEAVY METALS, MICROELEMENTS AND VITAMIN B2 IN THE DIETS OF WHITE RATS

   
Authors: Yermakova E.I., Papunidy K.H., Biktashev R.U.
   
Address: Federal Center of Toxicological Radiation and Biological Safety, Kazan.
   
Abstract: The article presents the results of research of combined heavy metals, microelements and vitamin B2 sorption by bentonite in experiments in vivo. To the tenth day of the experiment there was a constant decrease of microelements and vitamin B2 quantity in liver of rats. Microelements in the most degree adsorbed at combined fuse of animals by lead and cadmium. The content of iron and manganese was the smallest to the twentieth day of research and by 40,65 mg/kg and 3,01 mg/kg became less the control values. Quantity of copper on the thirtieth day decreased by 7,96 mg/kg, of zinc - by 44,48 mg/kg, of cobalt - by 0,464 mg/kg. During experiment the quantity of vitamin B2 in liver was decreased and on thirtieth day was less control values by 16,93 mg/kg. Bentonite in the most degree adsorbed vitamin B2 at phone of cadmium and lead contamination. Content of vitamin B2 was the smallest to thirtieth day of experiment and have trend to decrease throughout the experiment and was less by 23,61 mg/kg in comparison with control data. In this group to thirtieth day quantity of iron was less by 38,62 mg/kg, copper by 6,16 mg/kg, cobalt by 0,454 mg/kg. Contant of manganese was smallest to the twentieth day of research and reduction was 2,94 mg/kg.
   
Keywords: bentonite, adsorption, microelements, heavy metals, vitamins
   
   
   
Title:

THE CLINICAL AND HEMATOLOGICAL PARAMETERS OF LAYING HENS CROSS «HISEX BROUN» IN CHRONIC INFLUENCE DIOXIN IN SLIGHT DOSES

   
Authors: Papunidi K.Kh.; Korchemkin A.A.; Kadikov I. R.; Idiatov I. I.
   
Address: Federal Center for Toxicological, Radiation and Biological Safety, Kazan.
   
Abstract: This article contains the results of chronic influence of 2,3,7,8-tetrachlordibenzo-p-dioxin in slight doses on clinical- hematological characteristics of laying hens. For this we conducted of clinical researches weighting birds and defined contain of erythrocytes, leucocytes, hemoglobin. By results of researches was found out the clinical signs of intoxication was characterized by decreasing the consumption of fodder and water, general oppression, decreasing the movement activity, egg-laying qualities, then her termination, on poisoning experiment of subjects chickens by dioxin in doses 1/400 LD50, 1/800 LD50 è 1/1200 LD50. Analysis of hematological data showed oppression the function of hematopoietic organs that was characterized by decrease contain of erythrocytes, leucocytes, hemoglobin.
   
Keywords: 2,3,7,8-tetrachlordibenzo-p-dioxin, chronic influence, hens, egg-laying qualities, hematogenesises oppression
   
  Infectious pathology
   
Title:

APPLICATION OF DISK DIFFUSION TEST SENSITIVITY MICROORGANISMS TO ANTIBIOTICS IN THE VETERINARY

   
Authors: Violin B.V.; Gulyaeva A.Y.; Muravyeva V.B.
   
Address: FSFI «The All-Russian State Center of Quality and Standardization of Veterinary Drugs and Feed», Moscow.

   
Abstract: In the article we can see analysis of  using disk diffusion method and serial dilution method to assess the sensitivity of microorganisms to antibiotics. Conducting disk diffusion method requires strict compliance with the conditions of testing, correct and consistent procedures of quality control materials.
The disadvantage of this method is: no special standard disk to modern veterinary medicines: tylosin, tiamulin, ceftiofur, florfenicol, tulathromycin, enrofloxacin, norfloxacin, kitasomitsin; inability to use the disk diffusion method for determining the susceptibility of microorganisms to combine medicines. This method makes it possible to determine only the qualitative characteristics and to determine the minimum inhibitory concentrations of antibacterial agents. Also it is impossible to study the sensitivity of important pathogens as Mycoplasma spp., Chlamidya spp., Brachyspia hyodysenteriae, Fusobacterium spp., Bacteroides spp., Lawsonia intracellularis on the medium used in this method.   Serial dilution method is more reliable and accurate quantitative method, the results of which are much less dependent on conditions and materials that were used.
 Also, this method allows us to investigate any materia in any combination and ratio that plays an important role in value effectiveness  of combine medicines, or the study of synergistic and antagonistic properties of different compounds.
 A comprehensive value of the methods considered to be very important for clinicians because it allows to select the best of the two methods for determining the susceptibility of microorganisms to antimicrobial agents depending on the clinical situation and aim of the study.
   
Keywords: susceptibility testing, disk - diffusion method, serial dilution method, the minimum inhibitory concentration, antibiotics
   
   
   
Title:

ANTIMICROBIAL SENSITIVITY EVALUATION AS ONE OF THE CRITERIA TO STUDY THE RISK OF ANTIBIOTIC RESISTANCE

   
Authors: Muzyka V.P.
   
Address: State Research Institute for Veterinary Preparations and Feed Additives Control, Ukraine.
   
Abstract: The system of antimicrobial sensitivity of microorganisms are developed. It includes three consecutive steps: qualitative determination of antimicrobial sensitivity by disk-diffusion method; determination of minimum inhibitory concentration of antibiotics by method of successive dilutions; receiving of resistance microorganisms by passage from rising antibiotic concentrations.
   
Keywords: fntibiotics, àntimicrobial sensitivity of microorganisms, àantibiotic resistance
   
   
   
Title:

EPIDEMIC SITUATION ON HIGHLY DANGEROUS AND SOCIALLY IMPORTANT DISEASES IN THE RUSSIAN FEDERATION IN 2012

   
Authors: Petrova O.N.; Dudnikov S.A.
   
Address: FGBI «Federal Centre for Animal Health» (FGBI “ARRIAH”), Vladimir, Tel.: (4922) 52-99-67.
   
Abstract: Studies of the epidemic process  dynamics of highly dangerous and socially important diseases using retrospective analysis methods provide coordinated activities of veterinary services of country/region/subject aimed at maintenance of disease-free situation in the population of farm animals.
   
Keywords: retrospective analysis, epidemic situation, epidemic threshold
   
   
   
Title:

FITTING AND COMPARATIVE EFFICACY PROTECTIVE MAINTENANCE MEDIUM FOR THE CONSERVATION MYCOBACTERIUM BIRD TYPE AND ATYPICAL

   
Authors: Andriienko Y.V.; Selishcheva N.V.; Bogach N.V.
   
Address: FITTING AND COMPARATIVE EFFICACY PROTECTIVE MAINTENANCE MEDIUM  FOR THE CONSERVATION MYCOBACTERIUM BIRD TYPE AND ATYPICAL
   
Abstract: In the article is grounded the theory of long-term storages of mycobacterium cultures in the lyophilized state and what is the protective stabilized media to save biological properties of cultures can be used for this aim. Conducted selection and experimentally approved the set of protective stabilized media for the lyophilize of bird mycobacterium cultures and atypical. Developed the composition of protective stabilized media and given the chart of preparation of cultures for lyophilizing drying. As well the physicochemical properties of the dried specimen (color, structure, presence of admixtures) and native specimen (color, consistency, presence of admixtures, turbidity, solubility) were taken into account. Described in detail bacteriological method of research of cultures after drying, because it’s a very important moment taken into account specific differences and features of belonging of cultures to the different groups. Order of correct lyophilization and storages of different kinds cultures of mycobacterium will introduce huge possibilities for biofactories, research establishments, control institutes of save cultures long time without the losses of their viability, biochemical and biological properties. Similarly were analyzed adaptgene properties of different kinds of mycobacterium cultures in the extreme terms of survival (drying, dissolution) for them.
   
Keywords: mycobacterium, conservation, maintenance medium
   
   
   
Title:

THE EVALUATION OF THE SIGNIFICANCE OF SOME NOSOLOGICAL FORMS IN FORMATION OF NOSOLOGICAL PROFILE OF INFECTIOUS PATHOLOGY OF VARIOUS SPECIES OF ANIMALS, BIRDS AND FISH IN THE NIZHNY NOVGOROD REGION CONDITIONS

   
Authors: Pashkin A.V.; Pashkina Ju.V.; Taymusova E.N.; Chvala A.V.; Atrohova S.V.; Gorbunov P.A.; Elizarov A.P.
   
Address: Nizhny Novgorod State Agricultural Academy, Nizhny Novgorod.
   
Abstract: It was installed, that the nosological profile of infectious pathology of various wildlife species in Nizhniy Novgorod’s conditions has a pronounced regional particularities and it formed from a number both infectious (36,9 percents of total contagious pathology) so and parasitic (63,1%) systems. In 66,2% cases it functioned as a mono- (with involving only one kind of animals) and in 33,8% - as a polyhost system (with involving many kinds of animals).
The differences in the number of nozoforms in nosological profile of infectious pathology of different animals’ kinds were installed, not only on the territory of the region, but also in Russian Federation in the whole and it allowed making conclusion, that in the different regions of RF there is a specific set of the diseases different kinds of animals and the factors (the conditions), promoting their origin, spreading and liquidations. It is necessary to consider in correction (the improvement) system of measures on struggle against epizooty.
   
Keywords: nosological forms, infectious and parasitic pathology, animals, birds and fish
   
  Non-transmittable diseases
   
Title:

INFLUENCE OF VITA-FORSÅ BEE MEDICATION ON PREGNANT MUSTELA LUTREOLA

   
Authors: Gayzatullin R.R.; Sitdikov F.F.; Vafin I.F.
   
Address: Federal Center for Toxicological, Radiation and Biological Safety, Kazan.
   
Abstract: In this article we will cover the changes of hematological and biochemical indexes as well as the parameters of autarcesis and immunobiological responsiveness of pregnant Mustela Lutreola when applying the  Vita-forså bee medication. When applying the Vita-forså bee medication the increase of red and white blood cells amount, concentration increase of TP and decrease of ?-globulin in blood serum is indicated. The bee medicine stimulates the immune system of animals and positively affects the reproduction of female animals increasing the animal yield.
   
Keywords: Mustela Lutreola, natural resistance, apitherapenticals, pregnant female animal, whelping
   
   
   
Title:

CLINICAL-AND-LABORATORY INDICES OF SOWS WITH GESTOSIS SIGNS

   
Authors: Kotsarev V.N.; Gorokhov N.A.; Sulejmanov S.M.; Tolkachev I.S.; Mikaylov Å.V.; Papin N.E.; Chusova G.G.
   
Address: State Scientific Institution «All-Russian veterinary research institute of pathology, pharmacology and therapy» of Russian Academy of Agriculture Sciences, Voronezh.
   
Abstract: Some indices of the clinical status, biochemical status, morphological changes in placenta, offspring viability, parturient and postpartum complications spread were determined in the conditions of the pig-breeding complex. 28 Large White sows (15 animals with normal pregnancy and 13 with the symptom complex following abundant salivation, gritting teeth, pose of a “sitting dog”) were involved in the observation. It is stated that gestosis in sows is accompanied by hypertension (the systolic pressure increases by 6,8-22,8%, diastolic pressure - by 17,3-28,2%), proteinuria (urine protein content increases by 25,8 times), blood rheological properties changes (platelet number decreases by 25,8%) along with energy metabolism decrease (glucose decreases by 18,5%), hepatopathy manifestation (Alanine aminotransferase activity increases by 8,7%, Aspartate aminotransferase - by 19,0%), nephropathy (urea increases by 16,4%, creatinine increases by 9,9%), decrease of the non-enzymatic link of the antioxidant protection system (vitamin A content decreases by 1,4 times, vitamin E content decreases by 1,3 times), free radical oxidation activation (malonic dialdehyde level increases by 1,3 times) under stagnant hyperaemia, extravasates, haemorrhages, dystrophy and chorion villi fragmentation in placenta. All these things lead to intrauterine fetal development disorders (the number of underdeveloped piglets increases by 1,8 times, stillborn - by 2,2 times), labor disorders (primary labor atonia increases by 1,7 times, placenta detention increases by 2,3 times) and puerperal period disorders (postpartum diseases increase by 2,1 times and the affection of lobes of mammary gland by subclinical mastitis increases by 3,4 times). Thus, pregnancy pathologies of sows with abundant salivation, gritting teeth, pose of a “sitting dog” signs are characterized by hypertensia and proteinuria, progress under homeostasis disorder and are characterized by hemodynamic and morphological changes in placenta, promote parturient and postpartum complications and birth of underdeveloped and little viable piglets.
   
Keywords: sow, pregnancy, hypertensia, proteinuria, blood, placenta, postpartum complications
   
   
   
Title:

CELL-FREE PROBIOTICS AND SINBIOTICS ON THEIR BASIS - AN INNOVATIVE DIRECTION IN MAINTENANCE OF EFFICIENCY OF MODERN ANIMAL INDUSTRIES

   
Authors: 1 Neminushchaja L.A.; 1 Bobrovskaya I.V.; 1 Eremets N.K.; 1 Provotorova O.V.; 1 Eremets V.I.; 1 Vorobjeva G.I.; 1 Samujlenko A.J.; 2 Krasochko P.A.; 3 Saleeva I.P.
   
Address: 1 State scientific research department “All-Russian scientific research and technological institute of biological industry” of the Russian academy of agricultural sciences, Shchelkovo, Moscow Region.
2 Institute of experimental veterinary science of S.N.Vyshelessky, Minsk, Belarus.
3 GNU VNITIP Russian academy of agricultural sciences, Sergiev Posad.
   
Abstract: Article is devoted working out new probiotics metabolite type and sinbiotics complexes on their basis, and also efficiency of application such sinbiotics in animal industries.
   
Keywords: probiotics, prebiotics, sinbiotics, metabolite, efficiency, poultry farming, animal industries
   
   
   
Title:

MINERAL METABOLISM FOR COWS IN DEPENDENCE ON CHANGES OF GEOBIOCENOSIS IN GEOCHEMICAL ZONES OF UKRAINE

   
Authors: Doletskiy S.P.
   
Address: National Academy of Agrarian Sciences of Ukraine.
   
Abstract: The complex of clinic-morphological, biochemical and mass-spectrometer researches of the chain soil - water - forage - organism of animals had been conducted. The characteristic display of mineral exchange violations in the organism of cows in different geochemical areas was shown. The changes of steppe and Polåsye ecosystems, which substantially influenced on a mineral exchange in the organism of lactating cows had been set, predetermining his violation.
   
Keywords: mineral exchange, geo-biocenosis, geochemical zone, ecosystem, cows
   
   
   
Title:

APPLICATION OF ANTIOXIDANTS FOR TREATMENT OF FELINE CHRONIC ENDOGENOUS CHORIORETINITIS

   
Authors: Komissar A.B.
   
Address: Moscow State Academy of Veterinary Medicine and Biotechnology, Moscow, Russia.
   
Abstract: In the researches on cats with chronic endogenous chorioretinitis diagnosed by ophtalmoscopy, funduscopy, electroretinography, tear antioxidant activity measures, ultrasonography and biochemical profile was checked the efficiency of application antioxidants for treatment. There were 4 subgroups occurred in case of different tear drops: first (1) control subgroup received only dexametazone 0,1% 1 drop three times a day, second (2) group received dexametazone 0,1% 1 drop three times a day and Vizomitin 1 drop 1 times a day, third (3) subgroup had also received dexametazone in the same dose and Emoxipin 1 drop 2 times a day, the fourth group had been by dexametazone and both Emoxipin and Vizomitin treated. All subgroups were given Mexidol-Vet 50 mg in dosage 10 mg per kg twice a day for 14 days. Therapy was continued for 30 days. 64% of cats had improved positive changes considered in reducing of hemorrhagic lesions in fundus, normalization of optic disc vascularisation and the general condition, ERG component values increase, recovery of tear antioxidant activity.
   
Keywords: antioxidants, therapy, chronic endogenous chorioretinitis, cats
   
   
   
Title:

CLINICAL DIAGNOSTIC CRITERIA KERATOPATHY ANIMALS

   
Authors: Goncharova A.V.; Sotnikova L.F.
   
Address: FSBEU VPO «Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I.Scriabin».
   
Abstract: The aim of our study was to develop a clinical diagnostic criteria for diseases of the cornea, caused by different etiologies based on a comprehensive survey of the vision in animals. On the basis of an integrated methodological approach to the examination of eye grounded and identified six clinical forms of the course êeratopathy in animals with different color change cornea becomes red in the presence of her blood vessels that accompany chronic irritation, deep ulcerative keratitis or corneal injury, with endothelial or epithelial dystrophy various genesis cornea becomes blue hue, while important in diagnostics test is fluorescein, which is determined by which of the layers are responsible for cell turgor damaged cornea; outcome ulcerous processes accompanied by ingrowth of vessels into the cornea are scarring, wherein cornea becomes smoky blue-white color, with degenerative changes of the cornea portion becomes brilliant white color, as a substitute substance own corneal tissue may be lipids, or amyloid calcium is not observed by the inflammation of the cornea and conjunctiva, cornea black colored with corneal pigmentation melanin pigment deposited in the cells of the cornea during prolonged chronic stimulation in dogs and breakage of stratified squamous epithelium in cats, wherein the process is accompanied by necrosis stromal collagen detachment from each other, called corneal sequestration, with infiltration of inflammatory cells, corneal stroma and in the gathering of precipitates on the corneal endothelium becomes a yellow-green color. An integrated diagnostic approach to the study of the cornea in animals can deliver adequate and timely diagnosis based mainly on the change of color of the cornea and associated clinical symptoms.
   
Keywords: cornea, edema, vascularization, trauma, degeneration, tripe, white blood cells, pigment
   
   
   
Title:

INFLUENCE OF MINERAL SORBENT ON THE HEMATOLOGIC INDICATORS CALVES WITH DIARRHEA SYNDROME

   
Authors: Mikhaleva T.V.
   
Address: State Scientific Institution «Samara Research Veterinary Station» the Academy of Agricultural Sciences, Samara.
   
Abstract: Influence of mineral sorbent sorbi and antibiotic fluoroquinolones number politril on haematological parameters of blood of calves suffering gastroenteritis pathology Drug sorbi is a mineral opal-cristobalite feed additive of Flask moulding boxes - microporous cream íèñòàÿ sedimentary rock composed of amorphous silica (opal) with a mixture of clay substance, skeletal parts of organisms (diatoms and spicules flint sponges), mineral components (quartz, feldspar, glauconite). Feeding opal - cristobalite sorbent calves with non-specific gastroenteritis, improves the clinical condition of the animals and contributes to the restoration of physiological processes and indicators homeostasis internal environment of the body. Normalizes such hematologic display Ministers as erythrocytes, leukocytes, hematocrit value, the average volume of erythrocytes and erythrocyte sedimentation rate. In this connection, one should pay special attention to studying and the use of local natural resources, which are explored deposits of siliceous (opal- cristobalite) breeds of Samara region - moulding boxes, Syzran field.
   
Keywords: hematological parameters of blood, antibiotic, diarrhea calves
   
   
   
Title:

KARYOPATIC EFFECT OF THE «SPOROVIT» IN LABORATORY ANIMALS

   
Authors: Krasikova E.V.; Sivakova T.N.
   
Address: Perm State Agricultural Academy.
   
Abstract: In recent years studying of pathological action of various biological agents on a cell and a nucleus of a macro organism draws attention of the scientific many countries. In article karyopatic changes in somatic and sexual cells of laboratory mice after intraperitoneal injection of the bacterial preparation "Sporovit" are analyzed. It is established that the increase in a mitotic index in red marrow of mice under the influence of B.subtilis of a production strain occurs in 48 hours. In testicules of experimental animals also in 48 hours after single injection of this preparation the mitotic index decreases. Our researches confirmed low karyopatic activity of a strain of B.subtilis from the preparation "Sporovit", therefore, it is possible to appoint it as a probiotic at therapy of the various pathological conditions, being accompanied the expressed karyopatic effect.
   
Keywords: bacteria, marrow, testicules, mitosis
   
   
   
Title:

EFFECT OF PROBIOTICS SUBALIN ON INTESTIN Al MICROBIOCENOSIS YOUNG MINK

   
Authors: Gashkova I.V.; Okulovà I.I.; Beltyukova Z.N.; Domsky I.A.; Berezinà Y.À.
   
Address: Russian Research Institute of Game Management and Fur Farming RAAS, Kirov.
   
Abstract: Conducted haematological, biochemical, immunological, bacteriological studies in young mink under the influence of probiotic subalin. Found that the biological product increases the body's resistance by synthesis of interferon and stimulates your own specific and nonspecific reactions.
   
Keywords: lactobacilli, bifidobacteria, interferon, non-specific resistance of the microorganism
   
  Parasitology
   
Title:

DISTRIBUTION MONITHES DEPENDING ON CONDITIONS OF THE MAINTENANCE AND FEEDING GOATS IN FACILITIES OF NON-BLACK EARTH REGION AND MEDICAL ACTIONS WITH APPLICATION OF A PREPARATION MONIZ

   
Authors: Tsepilova I.I.
   
Address: Moscow State Academy of Veterinary Medicine and Biotechnology by K.I.Skryabin.
   
Abstract: In given article it is spoken about distribution monithes goats in Non-Black Earth Region of the Russian Federation. Cited the data on seasonal and age dynamics. Facilities with various types of the maintenance are characterized. Feeding animals is described. Cited the data on extensiveness  and intensity invasion. Primary terms of infection goats are specified. In fluence of ways of the housing and feeding on distribution of invasion. The data on industrial test of a preparation Moniz. Purpose - 1 ml on 10 kg of alive weight of a body. Efficiency has been counted up. Individual summer residence to each animal.
   
Keywords: monithes, goats, distribution, Moniz, invasion, helmints
   
  Physiology
   
Title:

PREVENTING AND MANAGING ATHEROSCLEROSIS: THE ROLE OF OMEGA-3 POLYUNSATURATED FATTY ACIDS (REVIEW)

   
Authors: Muhammed A.A.; Pavlova L.A.; Kurynina K.O.; Maksimov M.L.
   
Address: Sechenov I.M. First Moscow State Medical University, Moscow, Russia.
   
Abstract: Atherosclerosis, which is a pathogenetic substrate for many cardiovascular diseases, is the result of a complex interaction between the blood cholesterol and the cellular components of blood vessel walls. High blood cholesterol, male gender, age, diabetes, hypertension, smoking and poor diet are the risk factors that cause progression of atherosclerotic diseases and theirs complications, such as coronary heart disease, stroke, and myocardial infarction. Prevention and treatment of atherosclerotic diseases are usually based on trying to reduce the risk factors for atherosclerosis. Prophylaxis and therapy aimed to cure the risk factors, remains the main form of treatment this disease. Nowadays, there are many studies concerned about discovering a new nutritional factors of the atherosclerosis. The use of drugs of highly purified omega-3 fatty acids in combination with a "Mediterranean" diet could be an effective way to treat and prevent the atherosclerosis diseases, as well as any cardiovascular others.
   
Keywords: atherosclerosis, polyunsaturated fatty acids, omega-3, treatment, prevention, prophylaxis, coronary heart disease, poor diet, cholesterol, diet